"Funny" channels in cardiac mitochondria modulate membrane potential and oxygen consumption.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.033
Abstract: The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by a family of four genes (HCN1-4). All isoforms are expressed in the heart, HCN4 being the most abundant in the sinoatrial node (SAN). HCN channels are… read more here.
Keywords: mitochondria; hcn channels; oxygen consumption; membrane potential ... See more keywords
Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity.
Sign Up to like & getrecommendations! Published in 2018 at "Mitochondrion"
DOI: 10.1016/j.mito.2017.08.001
Abstract: Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ischemia/reperfusion (I/R)… read more here.
Keywords: oxidative stress; decreasing complex; stress; complex activity ... See more keywords
Sericin-mediated improvement of dysmorphic cardiac mitochondria from hypercholesterolaemia is associated with maintaining mitochondrial dynamics, energy production, and mitochondrial structure
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2055088
Abstract: Abstract Context Sericin is a component protein in the silkworm cocoon [Bombyx mori Linnaeus (Bombycidae)] that improves dysmorphic cardiac mitochondria under hypercholesterolemic conditions. This is the first study to explore cardiac mitochondrial proteins associated with… read more here.
Keywords: energy production; cardiac mitochondria; mitochondria hypercholesterolaemia; mitochondrial structure ... See more keywords
Cardiac Mitochondria Dysfunction in Dyslipidemic Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911488
Abstract: Dyslipidemia triggers many severe pathologies, including atherosclerosis and chronic inflammation. Several lines of evidence, including our studies, have suggested direct effects of dyslipidemia on cardiac energy metabolism, but details of these effects are not clear.… read more here.
Keywords: cardiac mitochondria; function; activity; mice ... See more keywords
Tunicamycin-Induced Endoplasmic Reticulum Stress Damages Complex I in Cardiac Mitochondria
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12081209
Abstract: Background: Induction of acute ER (endoplasmic reticulum) stress using thapsigargin contributes to complex I damage in mouse hearts. Thapsigargin impairs complex I by increasing mitochondrial calcium through inhibition of Ca2+-ATPase in the ER. Tunicamycin (TUNI)… read more here.
Keywords: endoplasmic reticulum; stress; stress damages; reticulum stress ... See more keywords