Molecular dynamics provides new insights into the mechanism of calcium signal transduction and interdomain interactions in cardiac troponin
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13009
Abstract: Understanding the regulation of cardiac muscle contraction at a molecular level is crucial for the development of therapeutics for heart conditions. Despite the availability of atomic structures of the protein components of cardiac muscle thin… read more here.
Keywords: molecular dynamics; cardiac muscle; cardiac troponin; tnc ... See more keywords
Maduramicin induces cardiac muscle cell death by the ROS‐dependent PTEN/Akt–Erk1/2 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27830
Abstract: Maduramicin (Mad), a polyether ionophore antibiotic, has been reported to be toxic to animals and humans because of being used at high doses or for long time, resulting in heart failure. However, the toxic mechanism… read more here.
Keywords: akt erk1; cardiac muscle; cell death; mad induced ... See more keywords
Advancing physiological maturation in human induced pluripotent stem cell‐derived cardiac muscle by gene editing an inducible adult troponin isoform switch
Sign Up to like & getrecommendations! Published in 2020 at "STEM CELLS"
DOI: 10.1002/stem.3235
Abstract: Advancing maturation of stem cell‐derived cardiac muscle represents a major barrier to progress in cardiac regenerative medicine. Cardiac muscle maturation involves a myriad of gene, protein, and cell‐based transitions, spanning across all aspects of cardiac… read more here.
Keywords: adult; isoform; cardiac muscle; maturation ... See more keywords
A Method for Markerless Tracking of the Strain Distribution of Actively Contracting Cardiac Muscle Preparations
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Mechanics"
DOI: 10.1007/s11340-020-00646-w
Abstract: Background Current techniques for tracking the displacement and strain patterns within contracting cardiac specimens often require ‘invasive’ markers to be fixed on the sample, offer only modest spatial resolution, and are computationally inefficient. Objective We… read more here.
Keywords: strain; strain distribution; contracting cardiac; cardiac muscle ... See more keywords
Lost in translation: Interpreting cardiac muscle mechanics data in clinical practice.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.12.021
Abstract: Current inotropic therapies improve systolic function in heart failure patients but also elicit undesirable side effects such as arrhythmias and increased intracellular Ca2+ transients. In order to maintain myocyte Ca2+ homeostasis, the increased cytosolic Ca2+… read more here.
Keywords: translation interpreting; lost translation; cardiac muscle; function ... See more keywords
Reciprocal Polarization of the Mitochondrial Ca2+ Uniporter and NA+-CA2+ Exchanger in Cardiac Muscle
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.729
Abstract: Control of myocardial energetics by Ca2+ signal propagation to the mitochondrial matrix includes local Ca2+ delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) to the inner mitochondrial membrane (IMM) through the Ca2+ uniporter (mtCU). Ca2+… read more here.
Keywords: ca2 exchanger; cardiac muscle; ca2 uniporter; ca2 ... See more keywords
Dose-dependent effect of Bisphenol-A on insulin signaling molecules in cardiac muscle of adult male rat.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.01.022
Abstract: Environmental contaminant, Bisphenol-A (BPA) is a xenoestrogen, an essential component used for the production of two classes of polymers such as polycarbonate and epoxy resin which disrupts the normal endocrine function. BPA has intense effects… read more here.
Keywords: effect; insulin; cardiac muscle; adult male ... See more keywords
Microscopic Findings in the Cardiac Muscle of Stranded Extreme Deep-Diving Cuvier's Beaked Whales (Ziphius cavirostris)
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927622000605
Abstract: Abstract Considerable information has been gained over the last few decades on several disease processes afflicting free-ranging cetaceans from a pathologist's point of view. Nonetheless, there is still a dearth of studies on the hearts… read more here.
Keywords: deep diving; beaked whales; cuvier beaked; diving cuvier ... See more keywords
A Potent Fluorescent Reversible-Covalent Inhibitor of Cardiac Muscle Contraction.
Sign Up to like & getrecommendations! Published in 2021 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00366
Abstract: Compounds that directly modulate the response of the cardiac sarcomere have potential in the treatment of cardiac disease. While a number of sarcomere activators have been discovered and extensively studied, very few inhibitors have been… read more here.
Keywords: potent fluorescent; muscle; cardiac muscle; troponin ... See more keywords
CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01893-w
Abstract: The precise assembly of actin-based thin filaments is crucial for muscle contraction. Dysregulation of actin dynamics at thin filament pointed ends results in skeletal and cardiac myopathies. Here, we discovered adenylyl cyclase-associated protein 2 (CAP2)… read more here.
Keywords: actin; muscle; cardiac muscle; thin filaments ... See more keywords
Changes in cardiac and muscle biomarkers following an uphill-only marathon
Sign Up to like & getrecommendations! Published in 2018 at "Research in Sports Medicine"
DOI: 10.1080/15438627.2017.1393750
Abstract: ABSTRACT The aim of the study was to evaluate changes in cardiac troponin I levels (cTnI) and the main biomarkers of skeletal muscle damage after an uphill-only marathon, along with its relationship with athletes’ physiological… read more here.
Keywords: uphill marathon; muscle; cardiac muscle; biomarkers following ... See more keywords