Analysis of Transcriptional Profiling of Chamber-Specific Human Cardiac Myocytes Derived from Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1484-6_20
Abstract: Differentiation protocols to direct cell fate decision from pluripotent stem cells to cardiac myocytes normally achieve high purity and quality of cells. Nonetheless, the highly specialized anatomy of the heart enables the possibility that acquisition… read more here.
Keywords: cardiac myocytes; transcriptional profiling; pluripotent stem; chamber specific ... See more keywords
Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytes
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DOI: 10.1007/978-3-319-54579-0_2
Abstract: Signaling through the diffusible second messenger, 3′,5′-cyclic adenosine monophosphate (cAMP) is critical to the regulation of cardiac function. Several different G-protein-coupled receptors, including β-adrenergic receptors, muscarinic receptors, and E-type prostaglandin receptors, elicit distinct responses using… read more here.
Keywords: cardiac myocytes; compartmentation cardiac; microdomains camp; camp compartmentation ... See more keywords
JS-K, a GST-activated nitric oxide donor prodrug, enhances chemo-sensitivity in renal carcinoma cells and prevents cardiac myocytes toxicity induced by Doxorubicin
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3359-9
Abstract: PurposeDoxorubicin, a highly effective and widely used anthracycline antibiotic in multiple chemotherapy regimens, has been limited by its cardiotoxicity. The aim of this study is to investigate the effect of nitric oxide donor prodrug JS-K… read more here.
Keywords: cardiac myocytes; carcinoma; apoptosis; toxicity ... See more keywords
Carnosine protects cardiac myocytes against lipid peroxidation products
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DOI: 10.1007/s00726-018-2676-6
Abstract: Endogenous histidyl dipeptides such as carnosine (β-alanine-l-histidine) form conjugates with lipid peroxidation products such as 4-hydroxy-trans-2-nonenal (HNE and acrolein), chelate metals, and protect against myocardial ischemic injury. Nevertheless, it is unclear whether these peptides protect… read more here.
Keywords: cardiac myocytes; lipid peroxidation; peroxidation products; carnosine ... See more keywords
Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.12.019
Abstract: We have previously demonstrated that inorganic polyphosphate (polyP) is a potent activator of the mitochondrial permeability transition pore (mPTP) in cardiac myocytes. PolyP depletion protected against Ca2+-induced mPTP opening, however it did not prevent and… read more here.
Keywords: polyp; chain; cardiac myocytes; inorganic polyphosphate ... See more keywords
Lipid Inclusions in Cardiac Myocytes - A Rare Case of Cardiolipotoxicity
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DOI: 10.1016/j.cardfail.2019.07.331
Abstract: Introduction The heart oxidizes fatty acids for its energy production. However, excessive accumulation of lipids due to various processes such as obesity, diabetes, heart failure (HF), myocardial ischemia, or infarction can result in damage to… read more here.
Keywords: heart; case; accumulation; lipid inclusions ... See more keywords
Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels
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DOI: 10.1016/j.celrep.2020.01.025
Abstract: SUMMARY Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive,… read more here.
Keywords: cardiac myocytes; late sodium; sumoylation nav1; sodium current ... See more keywords
Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in doxorubicin-induced apoptosis in rat cardiac myocytes.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2021.11.085
Abstract: BACKGROUND Oxidative stress is implicated in the pathogenesis of doxorubicin-induced apoptosis in cardiac myocytes. However, the precise mechanism remains uncertain. We identified an apoptosis-inducing humoral factor, in a conditioned medium from cardiac myocytes subjected to… read more here.
Keywords: cardiac myocytes; oraip; apoptosis; oxidative stress ... See more keywords
Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.03.001
Abstract: Class IIa histone deacetylases (HDACs) are transcriptional repressors whose nuclear export in the cardiac myocyte is associated with the induction of pathological gene expression and cardiac remodeling. Class IIa HDACs are regulated by multiple, functionally… read more here.
Keywords: cardiac myocytes; nuclear export; makap; hdac5 ... See more keywords
A high-throughput ratiometric method for imaging hypertrophic growth in cultured primary cardiac myocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular and Cellular Cardiology"
DOI: 10.1016/j.yjmcc.2019.04.001
Abstract: Maladaptive hypertrophy of cardiac myocytes increases the risk of heart failure. The underlying signaling can be triggered and interrogated in cultured neonatal ventricular myocytes (NRVMs) using sophisticated pharmacological and genetic techniques. However, the methods for… read more here.
Keywords: cardiac myocytes; method; high throughput; growth ... See more keywords
Hyperoxia Induces Inflammation and Cytotoxicity in Human Adult Cardiac Myocytes
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DOI: 10.1097/shk.0000000000000740
Abstract: ABSTRACT Supplemental oxygen (O2) is used as adjunct therapy in anesthesia, emergency, and intensive care medicine. We hypothesized that excessive O2 levels (hyperoxia) can directly injure human adult cardiac myocytes (HACMs). HACMs obtained from the… read more here.
Keywords: cardiac myocytes; adult cardiac; hyperoxia; human adult ... See more keywords