α2A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation
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DOI: 10.1038/s41598-018-23304-7
Abstract: Cardiomyopathy is a common complication associated with increased mortality in sepsis, but lacks specific therapy. Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α2A-adrenergic receptor (AR) blockade on septic cardiomyopathy. CLP-induced… read more here.
Keywords: cardiac endothelial; norepinephrine concentration; blockade attenuates; cardiac norepinephrine ... See more keywords