Targeting HIF‐α for robust prevascularization of human cardiac organoids
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3165
Abstract: Prevascularized 3D microtissues have been shown to be an effective cell delivery vehicle for cardiac repair. To this end, our lab has explored the development of self‐organizing, prevascularized human cardiac organoids by coseeding human cardiomyocytes… read more here.
Keywords: cardiac organoids; hif; human cardiac; prevascularization ... See more keywords
Inspiration from heart development: Biomimetic development of functional human cardiac organoids.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.07.021
Abstract: Recent progress in human organoids has provided 3D tissue systems to model human development, diseases, as well as develop cell delivery systems for regenerative therapies. While direct differentiation of human embryoid bodies holds great promise… read more here.
Keywords: cardiac organoids; heart development; human cardiac; cell ... See more keywords
Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-020-0539-4
Abstract: Environmental factors are the largest contributors to cardiovascular disease. Here we show that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated with the neurotransmitter noradrenaline model the structure of the human heart… read more here.
Keywords: cardiac organoids; myocardial infarction; drug; infarction ... See more keywords
Wnt signaling directs human pluripotent stem cells into vascularized cardiac organoids with chamber-like structures
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1059243
Abstract: Heart diseases are leading cause of death around the world. Given their unique capacity to self-renew and differentiate into all types of somatic cells, human pluripotent stem cells (hPSCs) hold great promise for heart disease… read more here.
Keywords: pluripotent stem; human pluripotent; cardiac organoids; wnt signaling ... See more keywords
Heart in a Dish: From Traditional 2D Differentiation Protocols to Cardiac Organoids
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.855966
Abstract: Human pluripotent stem cells (hPSCs) constitute a valuable model to study the complexity of early human cardiac development and investigate the molecular mechanisms involved in heart diseases. The differentiation of hPSCs into cardiac lineages in… read more here.
Keywords: differentiation; heart; dish traditional; cardiac organoids ... See more keywords
Improving Generation of Cardiac Organoids from Human Pluripotent Stem Cells Using the Aurora Kinase Inhibitor ZM447439
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9121952
Abstract: Drug-induced cardiotoxicity reduces the success rates of drug development. Thus, the limitations of current evaluation methods must be addressed. Human cardiac organoids (hCOs) derived from induced pluripotent stem cells (hiPSCs) are useful as an advanced… read more here.
Keywords: drug; stem cells; cardiac organoids; pluripotent stem ... See more keywords
Recent Advances in Generation of In Vitro Cardiac Organoids
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076244
Abstract: Cardiac organoids are in vitro self-organizing and three-dimensional structures composed of multiple cardiac cells (i.e., cardiomyocytes, endothelial cells, cardiac fibroblasts, etc.) with or without biological scaffolds. Since cardiac organoids recapitulate structural and functional characteristics of… read more here.
Keywords: generation vitro; cardiac organoids; advances generation; medicine ... See more keywords
Cell-free DNA as a potential biomarker of differentiation and toxicity in cardiac organoids.
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.83532
Abstract: Cell-free DNA (cfDNA) present in the bloodstream or other bodily fluids holds potential as a non-invasive diagnostic for early disease detection. However, it remains unclear what cfDNA markers might be produced in response to specific… read more here.
Keywords: cell free; cfdna; free dna; cardiac organoids ... See more keywords