Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45023-3
Abstract: Hypoxic exposure during development can have a profound influence on offspring physiology, including cardiac dysfunction, yet many reptile embryos naturally experience periods of hypoxia in buried nests. American alligators experimentally exposed to developmental hypoxia demonstrate… read more here.
Keywords: reprogramming cardiac; induced reprogramming; cardiac phenotype; american alligators ... See more keywords
Smoking accelerates renal cystic disease and worsens cardiac phenotype in Pkd1-deficient mice
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DOI: 10.1038/s41598-021-93633-7
Abstract: Smoking has been associated with renal disease progression in ADPKD but the underlying deleterious mechanisms and whether it specifically worsens the cardiac phenotype remain unknown. To investigate these matters, Pkd1-deficient cystic mice and noncystic littermates… read more here.
Keywords: cardiac phenotype; worsens cardiac; smoking; pkd1 deficient ... See more keywords
New insights into the correlation between genotype and cardiac phenotype in laminopathies
Sign Up to like & getrecommendations! Published in 2023 at "Europace"
DOI: 10.1093/europace/euad122.600
Abstract: Abstract Funding Acknowledgements Type of funding sources: None. Background Genotype-phenotype correlation and risk stratification for heart failure progression in patients with cardiolaminopathies are poorly defined. Purpose The primary aim of the present study is to… read more here.
Keywords: figure panel; phenotype; genotype; age ... See more keywords
Cardiac phenotype in ATP1A3-related syndromes
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DOI: 10.1212/wnl.0000000000010794
Abstract: Objective To define the risks and consequences of cardiac abnormalities in ATP1A3-related syndromes. Methods Patients meeting clinical diagnostic criteria for rapid-onset dystonia-parkinsonism (RDP), alternating hemiplegia of childhood (AHC), and cerebellar ataxia, areflexia, pes cavus, optic… read more here.
Keywords: atp1a3 related; cardiac phenotype; phenotype atp1a3; related syndromes ... See more keywords
Insights into the Cardiac Phenotype in 9p Deletion Syndrome: A Multicenter Italian Experience and Literature Review
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DOI: 10.3390/genes14010146
Abstract: Chromosome 9p deletion syndrome is a rare autosomal dominant disorder presenting with a broad spectrum of clinical features, including congenital heart defects (CHDs). To date, studies focused on a deep characterization of cardiac phenotype and… read more here.
Keywords: phenotype deletion; deletion; insights cardiac; cardiac phenotype ... See more keywords