Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells
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DOI: 10.1111/bph.13679
Abstract: Clemizole, a histamine H1 receptor antagonist has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. The aim of the present study was to investigate whether clemizole blocks cardiac… read more here.
Keywords: cardiac potassium; currents stably; hydrochloride blocks; clemizole hydrochloride ... See more keywords
Cardiac Potassium Channels: Physiological Insights for Targeted Therapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology and Therapeutics"
DOI: 10.1177/1074248417729880
Abstract: The development of novel drugs specifically directed at the ion channels underlying particular features of cardiac action potential (AP) initiation, recovery, and refractoriness would contribute to an optimized approach to antiarrhythmic therapy that minimizes potential… read more here.
Keywords: potassium channels; cardiac potassium; channels physiological; therapy ... See more keywords