Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner
Sign Up to like & getrecommendations! Published in 2020 at "Gut Microbes"
DOI: 10.1080/19490976.2020.1823801
Abstract: ABSTRACT Despite the existing association of gut dysbiosis and T cell inflammation in heart failure (HF), whether and how gut microbes contribute to T cell immune responses, cardiac fibrosis and dysfunction in HF remains largely… read more here.
Keywords: adverse cardiac; gut dysbiosis; cardiac pressure; pressure overload ... See more keywords
Neutrophils orchestrate early cardiac remodeling after cardiac pressure overload
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DOI: 10.1152/physiol.2024.39.s1.1476
Abstract: Cardiac pressure overload is a chronic condition where the left ventricle undergoes pathological hypertrophy and fibrosis ultimately causing heart failure. Increased myocardial stretch in left ventricular pressure overload initiates activation of an inflammatory and fibrotic… read more here.
Keywords: pressure; pressure overload; orchestrate early; physiology ... See more keywords
Sotagliflozin, a Dual SGLT1/2 Inhibitor, Improves Cardiac Outcomes in a Normoglycemic Mouse Model of Cardiac Pressure Overload
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.738594
Abstract: Selective SGLT2 inhibition reduces the risk of worsening heart failure and cardiovascular death in patients with existing heart failure, irrespective of diabetic status. We aimed to investigate the effects of dual SGLT1/2 inhibition, using sotagliflozin,… read more here.
Keywords: cardiac pressure; pressure overload; dual sglt1; mice ... See more keywords