β‐Adrenergic stimuli and rotating suspension culture enhance conversion of human adipogenic mesenchymal stem cells into highly conductive cardiac progenitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2994
Abstract: Clinical trials using human adipogenic mesenchymal stem cells (hAdMSCs) for the treatment of cardiac diseases have shown improvement in cardiac function and were proven safe. However, hAdMSCs do not convert efficiently into cardiomyocytes (CMs) or… read more here.
Keywords: conductive cardiac; cardiac progenitors; adipogenic mesenchymal; human adipogenic ... See more keywords
Isolating Embryonic Cardiac Progenitors and Cardiac Myocytes by Fluorescence-Activated Cell Sorting.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7714-7_9
Abstract: Isolation of highly purified populations of embryonic cardiomyocytes enables the study of congenital cardiac phenotypes at the cellular level. Fluorescent-activated cell sorting (FACS) is normally used to isolate fluorescently tagged cells. Here we describe the… read more here.
Keywords: cardiac progenitors; activated cell; isolating embryonic; cell sorting ... See more keywords
Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.101116
Abstract: Objective Heart disease risk can be programmed by intrauterine exposure to obesity. Dysregulating key transcription factors in cardiac progenitors can cause subsequent adult-onset heart disease. In this study, we investigated the transcriptional pathways that are… read more here.
Keywords: adult onset; heart; cardiac progenitors; heart disease ... See more keywords
Metabolic flux analyses to assess the differentiation of adult cardiac progenitors after fatty acid supplementation
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cell Research"
DOI: 10.1016/j.scr.2019.101458
Abstract: Myocardial infarction is the most prevalent of cardiovascular diseases and pharmacological interventions do not lead to restoration of the lost cardiomyocytes. Despite extensive stem cell therapy studies, clinical trials using cardiac progenitor cells have shown… read more here.
Keywords: cardiac progenitors; adult cardiac; fatty acid; acid supplementation ... See more keywords
Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.01.012
Abstract: Zaniar Ghazizadeh,* Faranak Fattahi, Mehdi Mirzaei, Delger Bayersaikhan, Jaesuk Lee, Sehyun Chae, Daehee Hwang, Kyunghee Byun, Mehdi Sharifi Tabar, Sara Taleahmad, Shahab Mirshahvaladi, Parisa Shabani, Hananeh Fonoudi, Paul A. Haynes, Hossein Baharvand, Nasser Aghdami, Todd… read more here.
Keywords: human escs; cardiac progenitors; isl1 cardiac; progenitors human ... See more keywords
Abstract 197: Transcription Factor Interactome in Human iPS-derived Cardiac Progenitors is Enriched for Proteins Associated With Congenital Heart Disease
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.197
Abstract: Congenital heart disease (CHD) affects ~1% of live births and remains the leading cause of mortality in infants. While large-scale genetic studies have uncovered genes associated with CHD, distinguishing variants that confer risk from the… read more here.
Keywords: derived cardiac; cardiac progenitors; heart disease; congenital heart ... See more keywords