Proteomic profiling of key transcription factors in the process of neonatal mouse cardiac regeneration capacity loss
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11192
Abstract: The heart lacks complete regeneration capacity. In mice, the cardiac apex can regenerate 1 day after birth, although 7 days after birth the repair occurs with a fibrous scar. However, the key transcription factors (TFs)… read more here.
Keywords: mouse cardiac; cardiac regeneration; regeneration; regeneration capacity ... See more keywords
Non-coding RNAs in Cardiac Regeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1671-9_9
Abstract: Cardiovascular disease is a leading cause of death worldwide, and with the dramatically increasing numbers of heart failure patients in the next 10 years, mortality will only increase [1]. For patients with end-stage heart failure, heart… read more here.
Keywords: stem cells; heart; cardiac regeneration; stem ... See more keywords
Direct Reprogramming, Epigenetics, and Cardiac Regeneration.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2017.05.009
Abstract: The discovery of induced pluripotent stem cells (iPSCs) has revolutionized regenerative medicine. Autologous iPSCs can be generated by introducing 4 stem cell-specific factors (Oct4, Sox2, Klf4, c-Myc) into fibroblasts. iPSCs can propagate indefinitely and differentiate… read more here.
Keywords: medicine; cardiac regeneration; direct cardiac; cardiac reprogramming ... See more keywords
Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting using the human amniotic fluid stem cell secretome.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.04.011
Abstract: BACKGROUND The adult mammalian heart retains residual regenerative capability via endogenous cardiac progenitor cell (CPC) activation and cardiomyocyte proliferation. We previously reported the paracrine cardioprotective capacity of human amniotic fluid-derived stem cells (hAFS) following ischemia… read more here.
Keywords: cardiac regeneration; hafs; human amniotic; amniotic fluid ... See more keywords
A Combination of Allogeneic Stem Cells Promotes Cardiac Regeneration.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.09.036
Abstract: BACKGROUND The combination of autologous mesenchymal stem cells (MSCs) and cardiac stem cells (CSCs) synergistically reduces scar size and improves cardiac function in ischemic cardiomyopathy. Whereas allogeneic (allo-)MSCs are immunoevasive, the capacity of CSCs to similarly… read more here.
Keywords: cardiac regeneration; combination; stem cells; allo mscs ... See more keywords
The Long Noncoding RNA CAREL Controls Cardiac Regeneration.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.04.085
Abstract: BACKGROUND Adult mammalian heart loses regeneration ability following ischemic injury due to the loss of cardiomyocyte mitosis. However, the molecular mechanisms underlying the post-mitotic nature of cardiomyocytes remain largely unknown. OBJECTIVES The purpose of this… read more here.
Keywords: heart; cardiac regeneration; regeneration; mir 296 ... See more keywords
Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2022.120371
Abstract: BACKGROUND Neonatal hearts have considerable regenerative potential within 7 days post birth (P7), but the rate of regeneration is extremely low after P7. Interestingly, lipid metabolism increases dramatically after P7. The similarities in these age profiles… read more here.
Keywords: acsl1; myocardial regeneration; lipid metabolism; cardiac regeneration ... See more keywords
Mesenchymal stromal cell-derived exosomes in cardiac regeneration and repair
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.05.003
Abstract: Mesenchymal stromal cell (MSC)-derived exosomes play a promising role in regenerative medicine. Their trophic and immunomodulatory potential has made them a promising candidate for cardiac regeneration and repair. Numerous studies have demonstrated that MSC-derived exosomes… read more here.
Keywords: medicine; cardiac regeneration; regeneration repair; cell ... See more keywords
Cardiac regeneration: Cardiomyocyte proliferation: a variable genetic trait?
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cardiology"
DOI: 10.1038/nrcardio.2017.133
Abstract: Frequency of mononucleated diploid cardiomyocytes underlies natural variation in heart regeneration. Nat. Genet. http://dx.doi.org/ 10.1038/ng.3929 (2017) MNDCM frequency is a good surrogate to predict improved postinjury outcome Reprinted from Patterson, M. et al. Frequency of… read more here.
Keywords: regeneration cardiomyocyte; cardiac regeneration; regeneration; cardiomyocyte proliferation ... See more keywords
Cutting the molecular brakes to achieve cardiac regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-020-00681-z
Abstract: It has been estimated that nearly 1 billion cardiomyocytes (CM) die in a typical acute myocardial infarction (MI). There is an ongoing search for safe, reliable, sufficient replacement strategy for the lost CM to restore… read more here.
Keywords: heart; cutting molecular; capacity; cardiac regeneration ... See more keywords
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical science"
DOI: 10.1042/cs20201408
Abstract: Posttranslational modification by SUMO is a key regulator of cell proliferation and can be readily reversed by a family of SUMO-specific proteases (SENPs), making SUMOylation an ideal regulatory mechanism for developing novel therapeutic strategies for… read more here.
Keywords: cardiac regeneration; sumoylation; senp2; proliferation ... See more keywords