The Long Non-coding RNA NR_045363 Regulates Cardiomyocyte Apoptosis and Cardiac Repair Through Activating P53 Signal Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biology international"
DOI: 10.1002/cbin.11374
Abstract: Long noncoding RNAs (lncRNAs) can participate in various biological behaviors, including regulating cell differentiation, proliferation and apoptosis. The investigators have previously confirmed that highly conserved lncRNA NR_045363 controls cardiomyocyte (CM) proliferation and cardiac repair. The… read more here.
Keywords: apoptosis; rna; cms; pathway ... See more keywords
Circadian influence on the microbiome improves heart failure outcomes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.09.006
Abstract: Myocardial infarction (MI) leading to heart failure (HF) is a major cause of death worldwide. Previous studies revealed that the circadian system markedly impacts cardiac repair post-MI, and that light is an important environmental factor… read more here.
Keywords: gut; heart failure; microbiome; physiology ... See more keywords
Insight into Heart-Tailored Architectures of Hydrogel to Restore Cardiac Functions after Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00650
Abstract: With permanent heart muscle injury or death, myocardial infarction (MI) is complicated by inflammatory, proliferation and remodeling phases from both the early ischemic period and subsequent infarct expansion. Though in situ re-establishment of blood flow… read more here.
Keywords: heart tailored; myocardial infarction; heart; cardiac repair ... See more keywords
Galunisertib-Loaded Gelatin Methacryloyl Hydrogel Microneedle Patch for Cardiac Repair after Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c05352
Abstract: Uncontrolled and excessive fibrosis after myocardial infarction (MI) in the peri-infarct zone leads to left ventricular remodeling and deterioration of cardiac function. Inhibiting fibroblast activation during the mature phase of cardiac repair improves cardiac remodeling… read more here.
Keywords: microneedle patch; myocardial infarction; gelatin methacryloyl; cardiac repair ... See more keywords
Dual Roles of Graphene Oxide To Attenuate Inflammation and Elicit Timely Polarization of Macrophage Phenotypes for Cardiac Repair.
Sign Up to like & getrecommendations! Published in 2018 at "ACS nano"
DOI: 10.1021/acsnano.7b09107
Abstract: Development of localized inflammatory environments by M1 macrophages in the cardiac infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the regulation of inflammation by M1 macrophages and their timely polarization toward regenerative M2… read more here.
Keywords: cardiac repair; timely polarization; inflammation; macrophage ... See more keywords
An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat9683
Abstract: Acellular patches embedded with encapsulated cell-secreted factors improve cardiac repair after acute myocardial infarction in rodents and pigs. Acellular advantage Cell therapy for cardiac remodeling after myocardial infarction is therapeutic, in part, because of paracrine… read more here.
Keywords: cardiac patch; myocardial infarction; infarction; cardiac repair ... See more keywords
Abstract 15876: Tie1 is Essential for Cardiac Repair and Myocardial Regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.15876
Abstract: Introduction: Cardiac lymphatics are essential in resolving interstitial fluid and inflammatory infiltrate after a myocardial infarction in adults. Little is known about the role of the lymphatic s... read more here.
Keywords: repair myocardial; 15876 tie1; abstract 15876; tie1 essential ... See more keywords
Maximizing Cardiac Repair: Should We Focus on the Cells or on the Matrix?
Sign Up to like & getrecommendations! Published in 2017 at "Circulation research"
DOI: 10.1161/circresaha.116.309959
Abstract: A major characteristic of stem cells is their ability to respond to their environment and differentiate accordingly; yet, in the context of cardiac repair, where stem or progenitor cells are delivered into injured myocardium, the… read more here.
Keywords: maximizing cardiac; tissue; repair focus; cardiac repair ... See more keywords
Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.320781
Abstract: Background: Myocardial infarction (MI) elicits cardiac fibroblast activation and extracellular matrix (ECM) deposition to maintain the structural integrity of the heart. Recent studies demonstrate that Fap (fibroblast activation protein)—a prolyl-specific serine protease—is an important marker… read more here.
Keywords: inhibition fap; inhibition; fap; angiogenesis ... See more keywords
Iron Regulator Hepcidin Impairs Macrophage-Dependent Cardiac Repair After Injury
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.118.034545
Abstract: Background: Defective systemic and local iron metabolism correlates with cardiac disorders. Hepcidin, a master iron sensor, actively tunes iron trafficking. We hypothesized that hepcidin could play a key role to locally regulate cardiac homeostasis after… read more here.
Keywords: acute myocardial; mice; hepcidin; cardiac repair ... See more keywords
Long Noncoding RNA CPR (Cardiomyocyte Proliferation Regulator) Regulates Cardiomyocyte Proliferation and Cardiac Repair.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.118.035832
Abstract: BACKGROUND The adult mammalian cardiomyocytes lose their proliferative capacity, which is responsible for cardiac dysfunction and heart failure following injury. The molecular mechanisms underlying the attenuation of adult cardiomyocyte proliferation remain largely unknown. Because long… read more here.
Keywords: cpr; proliferation cardiac; cardiomyocyte proliferation; cardiac repair ... See more keywords