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   Articles with "cardiac repolarization" as a keyword



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A Single Supratherapeutic Dose of Atogepant Does Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized, Single‐Dose, Phase 1 Crossover Trial

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recommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.940

Abstract: Atogepant is a selective, oral calcitonin gene–related peptide receptor antagonist in development for preventive treatment of migraine. This randomized, double‐blind, phase 1 crossover study evaluated the cardiac repolarization effect of a single supratherapeutic (300 mg)… read more here.

Keywords: dose atogepant; cardiac repolarization; time; phase crossover ... See more keywords
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Single Therapeutic and Supratherapeutic Doses of Ubrogepant Do Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized Trial

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recommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"

DOI: 10.1002/cpt.1696

Abstract: Ubrogepant is a novel, oral calcitonin gene–related peptide receptor antagonist currently under US Food and Drug Administration (FDA) review for the acute treatment of migraine attacks. This double‐blind, four‐period crossover study compared the cardiac repolarization… read more here.

Keywords: single therapeutic; cardiac repolarization; healthy adults; therapeutic supratherapeutic ... See more keywords
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A phase 2 study to assess the pharmacokinetics and pharmacodynamics of CPX-351 and its effects on cardiac repolarization in patients with acute leukemias

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recommendations! Published in 2019 at "Cancer Chemotherapy and Pharmacology"

DOI: 10.1007/s00280-019-03856-9

Abstract: PurposeDaunorubicin can induce left ventricular dysfunction and QT interval prolongation. This study assessed the effects of CPX-351, a liposomal encapsulation of cytarabine and daunorubicin, on cardiac repolarization.MethodsTwenty-six adults with acute leukemia were treated with CPX-351… read more here.

Keywords: cpx 351; cardiac repolarization; phase study; cytarabine daunorubicin ... See more keywords
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Relative QT interval prolongation and electrical inhomogeneity of cardiac repolarization in childhood obesity

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recommendations! Published in 2017 at "Progress in Pediatric Cardiology"

DOI: 10.1016/j.ppedcard.2017.08.001

Abstract: Abstract Objective Studies in adults demonstrated an association of obesity with prolongation of cardiac repolarization and an increased risk of ventricular arrhythmia and sudden cardiac death. The aim of this study was to evaluate potential… read more here.

Keywords: childhood obesity; cardiac repolarization; interval prolongation; prolongation ... See more keywords
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Association of sleep-disordered breathing and disturbed cardiac repolarization in patients with ST-segment elevation myocardial infarction.

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recommendations! Published in 2017 at "Sleep medicine"

DOI: 10.1016/j.sleep.2017.01.007

Abstract: OBJECTIVE In patients with ST-segment elevation myocardial infarction (STEMI), disturbed cardiac repolarization before percutaneous coronary intervention (PCI) is a risk factor for malignant ventricular arrhythmia. We tested the hypothesis that sleep-disordered breathing (SDB) in patients… read more here.

Keywords: disturbed cardiac; cardiac repolarization; segment elevation; patients segment ... See more keywords
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Human electronegative low-density lipoprotein modulates cardiac repolarization via LOX-1-mediated alteration of sarcolemmal ion channels

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-10503-x

Abstract: Dyslipidemia is associated with greater risk of ventricular tachyarrhythmias in patients with cardiovascular diseases. We aimed to examine whether the most electronegative subfraction of low-density lipoprotein (LDL), L5, is correlated with QTc prolongation in patients… read more here.

Keywords: cardiac repolarization; via lox; density lipoprotein; lox ... See more keywords
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Altered Cardiac Repolarization in Chronic Obstructive Pulmonary Disease

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recommendations! Published in 2022 at "Turkish Thoracic Journal"

DOI: 10.5152/turkthoracj.2022.21075

Abstract: OBJECTIVE Altered cardiac repolarization is an important mechanism in the development of malignant cardiac arrhythmia and in the occurrence of sudden cardiac death. It is known that the risk of cardiac arrhythmia and sudden death… read more here.

Keywords: repolarization; obstructive pulmonary; chronic obstructive; pulmonary disease ... See more keywords