Discovery and progress of direct cardiac reprogramming
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2466-4
Abstract: Cardiac disease remains a major cause of death worldwide. Direct cardiac reprogramming has emerged as a promising approach for cardiac regenerative therapy. After the discovery of MyoD, a master regulator for skeletal muscle, other single… read more here.
Keywords: direct cardiac; progress direct; cardiac reprogramming; cardiac ... See more keywords
Direct Reprogramming, Epigenetics, and Cardiac Regeneration.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2017.05.009
Abstract: The discovery of induced pluripotent stem cells (iPSCs) has revolutionized regenerative medicine. Autologous iPSCs can be generated by introducing 4 stem cell-specific factors (Oct4, Sox2, Klf4, c-Myc) into fibroblasts. iPSCs can propagate indefinitely and differentiate… read more here.
Keywords: medicine; cardiac regeneration; direct cardiac; cardiac reprogramming ... See more keywords
Boosters and barriers for direct cardiac reprogramming
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.04.013
Abstract: &NA; Heart disease is currently the most significant cause of morbidity and mortality worldwide, which accounts for approximately 33% of all deaths. Recently, a promising and alchemy‐like strategy has been developed called direct cardiac reprogramming,… read more here.
Keywords: efficiency direct; direct cardiac; boosters barriers; cardiac reprogramming ... See more keywords
Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction
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DOI: 10.1161/circulationaha.121.058655
Abstract: Background: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellular matrix after myocardial infarction (MI) to form fibrosis, leading to cardiac dysfunction and heart failure. Therapies that can regenerate the myocardium… read more here.
Keywords: cardiac reprogramming; cardiac function; fibrosis chronic; myocardial infarction ... See more keywords
Abstract 543: Clinical Development of Cardiac Reprogramming Gene Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.543
Abstract: Heart failure affects an estimated 38 million people worldwide and is typically caused by cardiomyocyte (CM) loss or dysfunction. Although CMs have limited ability to regenerate, a large pool of non-myocytes, including cardiac fibroblasts (CFs),… read more here.
Keywords: gene therapy; safety; cardiac reprogramming; cardiac ... See more keywords
Abstract Thu032: Systematic CRISPR Knockout Screen Uncovers Epigenetic Barriers to Direct Cardiac Reprogramming
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.thu032
Abstract: Background: The direct conversion of human fibroblasts into induced cardiomyocytes (iCMs) holds great promise for generating mature cardiomyocytes for clinical applications. However, the process remains inefficient, and the underlying reprogramming mechanisms are not well understood.… read more here.
Keywords: ctnt; direct cardiac; epigenetic barriers; crispr ... See more keywords
Nucleosome repositioning in cardiac reprogramming
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DOI: 10.1371/journal.pone.0317718
Abstract: Early events in the reprogramming of fibroblasts to cardiac muscle cells are unclear. While various histone undergo modification and re-positioning, and these correlate with the activity of certain genes, it is unknown if these events… read more here.
Keywords: cardiac muscle; nucleosome repositioning; muscle; repositioning cardiac ... See more keywords