Luminal addition of non-permeant Eu3+ interferes with luminal Ca2+ regulation of the cardiac ryanodine receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2019.107449
Abstract: Dysregulation of the cardiac ryanodine receptor (RYR2) by luminal Ca2+ has been implicated in a life-threatening, stress-induced arrhythmogenic disease. The mechanism of luminal Ca2+-mediated RYR2 regulation is under debate, and it has been attributed to… read more here.
Keywords: mechanism; luminal ca2; eu3; cardiac ryanodine ... See more keywords
Molecular Clustering of Skeletal and Cardiac Ryanodine Receptors
Sign Up to like & getrecommendations! Published in 2018 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927618006645
Abstract: Contraction of skeletal and cardiac muscles is triggered by transient increase of cytosolic Ca concentration. Such Ca transient is originated from the massive release of Ca stored in the sarco/endoplasmic reticulum (SR), via intracellular Ca… read more here.
Keywords: molecular clustering; skeletal cardiac; cardiac ryanodine; ryanodine receptors ... See more keywords
Current management of inherited arrhythmia syndromes associated with the cardiac ryanodine receptor
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Cardiology"
DOI: 10.1097/hco.0000000000001051
Abstract: Purpose of review Gain-of-function variants in the gene encoding the cardiac ryanodine receptor (RYR2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). The exercise stress test (EST) has long been fundamental in diagnosis and management,… read more here.
Keywords: arrhythmia; ryanodine receptor; cardiac ryanodine; management ... See more keywords
FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0169
Abstract: Cardiac ryanodine receptors (RyR2) release the Ca2+ from intracellular stores that is essential for cardiac myocyte contraction. The ion channel opening is tightly regulated by intracellular factors, including the FK506 binding proteins, FKBP12 and FKBP12.6.… read more here.
Keywords: physiology; fkbp12; negative cooperativity; cardiac ryanodine ... See more keywords
Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.51602
Abstract: The effects of the immunophilins, FKBP12 and FKBP12.6, and phosphorylation on type II ryanodine receptor (RyR2) arrangement and function were examined using correlation microscopy (line scan confocal imaging of Ca2+ sparks and dual-tilt electron tomography)… read more here.
Keywords: cardiac ryanodine; ryanodine receptor; ryr2; phosphorylation ... See more keywords