LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "cardiac sodium" as a keyword



Photo by mikeaustin from unsplash

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.

Sign Up to like & get
recommendations! Published in 2018 at "Structure"

DOI: 10.1016/j.str.2018.03.005

Abstract: The function of the human cardiac sodium channel (NaV1.5) is modulated by the Ca2+ sensor calmodulin (CaM), but the underlying mechanism(s) are controversial and poorly defined. CaM has been reported to bind in a Ca2+-dependent… read more here.

Keywords: cardiac sodium; cam; sodium channel; human cardiac ... See more keywords
Photo from wikipedia

Modulation of the cardiac sodium channel NaV1.5 peak and late currents by NAD+ precursors.

Sign Up to like & get
recommendations! Published in 2020 at "Journal of molecular and cellular cardiology"

DOI: 10.1016/j.yjmcc.2020.01.013

Abstract: RATIONALE The cardiac sodium channel NaV1.5, encoded by SCN5A, produces the rapidly inactivating depolarizing current INa that is responsible for the initiation and propagation of the cardiac action potential. Acquired and inherited dysfunction of NaV1.5… read more here.

Keywords: cells expressing; ina; hek293 cells; cardiac sodium ... See more keywords
Photo from wikipedia

Reversible lysine acetylation: Another layer of post-translational regulation of the cardiac sodium channel

Sign Up to like & get
recommendations! Published in 2017 at "Channels"

DOI: 10.1080/19336950.2017.1340015

Abstract: Nav1.5, the voltage-gated cardiac Na C channel, conducts the inward NaC current (INa), which is the main depolarizing current responsible for initiation and propagation of the cardiac action potential. Mutations in SCN5A, the gene encoding… read more here.

Keywords: channel; cardiac sodium; post translational; nav1 ... See more keywords
Photo from wikipedia

Microtubule plus-end tracking proteins: novel modulators of cardiac sodium channels and arrhythmogenesis.

Sign Up to like & get
recommendations! Published in 2023 at "Cardiovascular research"

DOI: 10.1093/cvr/cvad052

Abstract: The cardiac sodium channel NaV1.5 is an essential modulator of cardiac excitability, with decreased NaV1.5 levels at the plasma membrane and consequent reduction in sodium current (INa) leading to potentially lethal cardiac arrhythmias. NaV1.5 is… read more here.

Keywords: intercalated disc; sodium; interacting proteins; membrane ... See more keywords
Photo from wikipedia

Anti‐inflammatory effects of cannabidiol against lipopolysaccharides in cardiac sodium channels

Sign Up to like & get
recommendations! Published in 2022 at "British Journal of Pharmacology"

DOI: 10.1111/bph.15936

Abstract: Sepsis, caused by a dysregulated response to infections, can lead to cardiac arrhythmias. However, the mechanisms underlying sepsis‐induced inflammation, and how inflammation provokes cardiac arrhythmias, are not well understood. We hypothesized that cannabidiol (CBD) may… read more here.

Keywords: sodium channels; effects cannabidiol; anti inflammatory; inflammatory effects ... See more keywords
Photo by nci from unsplash

A cardiac sodium channel mutation associated with epinephrine‐induced marked QT‐prolongation

Sign Up to like & get
recommendations! Published in 2020 at "Journal of Cardiovascular Electrophysiology"

DOI: 10.1111/jce.14572

Abstract: The hereditary long QT syndrome (LQTS) is an important cause of polymorphous ventricular tachycardia (torsades de pointes) and sudden cardiac death in otherwise young and healthy individuals. Clinically, this condition is caused by delayed ventricular… read more here.

Keywords: mutation associated; sodium channel; epinephrine induced; cardiac sodium ... See more keywords
Photo from wikipedia

Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias

Sign Up to like & get
recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23031381

Abstract: Nav1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Nav1.5 undergoes strict genomic… read more here.

Keywords: genomic regulatory; cardiac arrhythmias; sodium channel; non genomic ... See more keywords
Photo by homajob from unsplash

Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel NaV1.5

Sign Up to like & get
recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23042225

Abstract: The cardiac sodium ion channel (NaV1.5) is a protein with four domains (DI-DIV), each with six transmembrane segments. Its opening and subsequent inactivation results in the brief rapid influx of Na+ ions resulting in the… read more here.

Keywords: mouth; channel pore; site; cardiac sodium ... See more keywords
Photo from wikipedia

Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current INa by Lamotrigine; A Potential for Acquired Arrythmias

Sign Up to like & get
recommendations! Published in 2022 at "Pharmaceuticals"

DOI: 10.3390/ph15101208

Abstract: Lamotrigine is widely prescribed to treat bipolar neurological disorder and epilepsy. It exerts its antiepileptic action by blocking voltage-gated sodium channels in neurons. Recently, the US Food and Drug Administration issued a warning on the… read more here.

Keywords: sodium; current ina; sodium current; cardiac sodium ... See more keywords