microRNAs and cardiac stem cells in heart development and disease.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.05.032
Abstract: Cumulative evidence has proven that proliferation, differentiation and migration of cardiac stem cells (CSCs) dominate early heart development and contribute to the later occurrence of heart disease. Among other mechanisms, microRNAs work as the 'fine-tuning'… read more here.
Keywords: heart; cardiac stem; disease; heart development ... See more keywords
Protective effect of antioxidant Tempol on cardiac stem cells in chronic pressure overload hypertrophy
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.02.054
Abstract: Aims: Cardiac hypertrophy, an independent risk factor for cardiac failure; is associated with oxidative stress. Decline in the proportion of healthy cardiac stem cells (CSCs), possibly mediated by oxidative stress can lead to cardiac failure.… read more here.
Keywords: cardiac stem; hypertrophy; stem; stem cells ... See more keywords
Autologous and allogeneic cardiac stem cell therapy for cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2017.05.024
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Stem cell therapy is one of the most promising therapeutic innovations to help restore cardiac structure and function after ischemic insults to the heart. However, phase I and… read more here.
Keywords: csc; cardiac stem; cell therapy; stem cell ... See more keywords
Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease
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DOI: 10.1038/s41440-018-0015-7
Abstract: Cardiac stem cells (CSCs) play a vital role in cardiac remodeling. Uncontrolled hypertension leads to cardiac hypertrophy, followed by cardiac failure. Pathological remodeling is associated with enhanced oxidative stress. Decreased cardiac stem cell efficiency is… read more here.
Keywords: heart; cardiac stem; stem cell; stem ... See more keywords
Biologically active constituents of the secretome of human W8B2+ cardiac stem cells
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DOI: 10.1038/s41598-018-19855-4
Abstract: The benefits of adult stem cells for repair of the heart have been attributed to the repertoire of salutary paracrine activities they appear to exert. We previously isolated human W8B2+ cardiac stem cells (CSCs) and… read more here.
Keywords: w8b2 cardiac; human w8b2; cardiac stem; biologically active ... See more keywords
P5370Pulmonary pressure overload stimulates cardiac stem or progenitor cell-derived cardiac regeneration in the right ventricular area
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.0335
Abstract: The number of patients with right heart failure due to pulmonary hypertension has been increasing. Although several drugs have reportedly improved pulmonary hypertension, no treatments have been established for decompensated right heart failure. The heart… read more here.
Keywords: cardiac stem; regeneration; stem progenitor; cell ... See more keywords
The effect of allogeneic cardiac stem cells in left ventricular geometry and function in a rat model of myocardial infarction
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Therapeutics"
DOI: 10.1111/1755-5922.12313
Abstract: BACKGROUND The development of heart failure after acute myocardial infarction (MI) was related to left ventricular (LV) pathological remodeling and dysfunction. Cardiac stem cells (CSCs) provided a new option to treat acute MI. This study… read more here.
Keywords: cardiac stem; geometry function; myocardial infarction; geometry ... See more keywords
Bmi‐1 high‐expressing cells enrich cardiac stem/progenitor cells and respond to heart injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13889
Abstract: Bmi‐1 gene is well recognized as an oncogene, but has been recently demonstrated to play a role in the self‐renewal of tissue‐specific stem cells. By using Bmi‐1GFP/+ mice, we investigated the role of Bmi‐1 in… read more here.
Keywords: heart; progenitor cells; cardiac stem; bmi ... See more keywords
Adult Cardiac Stem Cell Concept and the Process of Science
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DOI: 10.1161/circulationaha.118.036407
Abstract: Modern reperfusion treatment for the early stages of acute myocardial infarction, which is really quite miraculous, if you pause to think about it, arose from a fundamental understanding of coronary thrombosis. Might we someday also… read more here.
Keywords: cell; adult cardiac; cardiac stem; stem ... See more keywords
Effects of Cardiotoxins on Cardiac Stem and Progenitor Cell Populations
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.624028
Abstract: As research and understanding of the cardiotoxic side-effects of anticancer therapy expands further and the affected patient population grows, notably the long-term survivors of childhood cancers, it is important to consider the full range of… read more here.
Keywords: cardiac stem; stem; progenitor cell; stem progenitor ... See more keywords