Post-Maturation Reinforcement of 3d-Printed Vascularized Cardiac Tissues.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202302229
Abstract: Despite advances in biomaterials engineering, a large gap remains between the weak mechanical properties that can be achieved with natural materials and the strength of synthetic materials. Here, we present a method for reinforcing an… read more here.
Keywords: reinforcement; post maturation; cardiac tissues; vascularized cardiac ... See more keywords
Contributions of bone morphogenetic proteins in cardiac repair cells in three‐dimensional in vitro models and angiogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2460
Abstract: One of the main efforts in myocardial tissue engineering is towards designing cardiac tissues able to rescue the reduction in heart function once implanted at the site of myocardial infarction. To date, the efficiency of… read more here.
Keywords: morphogenetic proteins; cardiac tissues; bone morphogenetic; proteins cardiac ... See more keywords
Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0668-1_13
Abstract: Engineered cardiac tissues hold tremendous promise for in vitro drug discovery, studies of heart development and disease, and therapeutic applications. Here, we describe a versatile "frame-hydrogel" methodology to generate engineered cardiac tissues with highly mature… read more here.
Keywords: methodology; hydrogel methodology; frame hydrogel; engineered cardiac ... See more keywords
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0830-2_10
Abstract: The delivery of cells into damaged myocardium induces limited cardiac regeneration due to extensive cell death. In an effort to limit cell death, our lab formulates three-dimensional matrices as a delivery system for cell therapy.… read more here.
Keywords: human induced; engineered cardiac; cardiac tissues; pluripotent stem ... See more keywords
Engineering Functional Cardiac Tissues for Regenerative Medicine Applications
Sign Up to like & getrecommendations! Published in 2019 at "Current Cardiology Reports"
DOI: 10.1007/s11886-019-1178-9
Abstract: Purpose of ReviewTissue engineering has expanded into a highly versatile manufacturing landscape that holds great promise for advancing cardiovascular regenerative medicine. In this review, we provide a summary of the current state-of-the-art bioengineering technologies used… read more here.
Keywords: medicine; engineering; regenerative medicine; cardiac tissues ... See more keywords
Bioprinting Approaches to Engineering Vascularized 3D Cardiac Tissues
Sign Up to like & getrecommendations! Published in 2019 at "Current Cardiology Reports"
DOI: 10.1007/s11886-019-1179-8
Abstract: 3D bioprinting technologies hold significant promise for the generation of engineered cardiac tissue and translational applications in medicine. To generate a clinically relevant sized tissue, the provisioning of a perfusable vascular network that provides nutrients… read more here.
Keywords: approaches engineering; engineered cardiac; tissue; cardiac tissues ... See more keywords
In Situ and Quantitative Monitoring of Cardiac Tissues Using Programmable Scanning Electrochemical Microscopy.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01919
Abstract: In vitro cardiac tissue model holds great potential as a powerful platform for drug screening. Respiratory activity, contraction frequency, and extracellular H2O2 levels are the three key parameters for determining the physiological functions of cardiac… read more here.
Keywords: situ quantitative; frequency; microscopy; h2o2 ... See more keywords
Nanoparticle-Based Hybrid Scaffolds for Deciphering the Role of Multi-Modal Cues in Cardiac Tissue Engineering.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b03050
Abstract: Myocardial microenvironment plays a decisive role in guiding the function and fate of cardiomyocytes and engineering this extracellular niche holds great promises for cardiac tissue regeneration. Platforms utilizing hybrid hydrogels containing various types of conductive… read more here.
Keywords: hybrid scaffolds; gelma; cardiac tissue; engineered cardiac ... See more keywords
Cardiomyocyte dedifferentiation and remodeling in 3D scaffolds to generate the cellular diversity of engineering cardiac tissues.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm01003c
Abstract: The use of engineered cardiac tissues (ECTs) is a new strategy for the repair and replacement of cardiac tissues in patients with myocardial infarction, particularly at late stages. However, the mechanisms underlying the development of… read more here.
Keywords: cardiac tissues; scaffold microenvironment; cellular diversity; cardiomyocyte dedifferentiation ... See more keywords
Recent advancements in cardiovascular bioprinting and bioprinted cardiac constructs.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d0bm01428a
Abstract: Cardiovascular diseases (CVDs) are the leading causes of mortality globally that demand the application of tissue engineering strategies to repair damaged tissues. Conventional tissue engineering approaches such as particulate leaching, hydrogels, gas foaming, solvent casting… read more here.
Keywords: bioprinting; recent advancements; cardiac tissues; advancements cardiovascular ... See more keywords
Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells"
DOI: 10.1093/stmcls/sxac022
Abstract: Abstract Human pluripotent stem cells (hPSCs) are expected to be a promising cell source in regenerative medicine and drug discovery for the treatment of various intractable diseases. An approach for creating a 3-dimensional (3D) structure… read more here.
Keywords: pluripotent stem; heart; cardiac tissues; stem cells ... See more keywords