Cardiac voltage-gated sodium channel expression and electrophysiological characterization of the sodium current in the zebrafish (Danio rerio) ventricle.
Sign Up to like & getrecommendations! Published in 2018 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2018.04.002
Abstract: Na+ channel α-subunit composition of the zebrafish heart and electrophysiological properties of Na+ current (INa) of zebrafish ventricular myocytes were examined. Eight Na+ channel α-subunits were expressed in both atrium and ventricle of the zebrafish… read more here.
Keywords: cardiac voltage; atrium ventricle; channel; ventricle ... See more keywords
Life Cycle of the Cardiac Voltage-Gated Sodium Channel NaV1.5
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.609733
Abstract: Cardiac voltage-gated sodium channel NaV1.5, encoded by SCN5A, is crucial for the upstroke of action potential and excitation of cardiomyocytes. NaV1.5 undergoes complex processes before it reaches the target membrane microdomains and performs normal functions.… read more here.
Keywords: voltage gated; cardiac voltage; sodium channel; gated sodium ... See more keywords
Coupling the Cardiac Voltage-Gated Sodium Channel to Channelrhodopsin-2 Generates Novel Optical Switches for Action Potential Studies
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12100907
Abstract: Voltage-gated sodium (Na+) channels respond to short membrane depolarization with conformational changes leading to pore opening, Na+ influx, and action potential (AP) upstroke. In the present study, we coupled channelrhodopsin-2 (ChR2), the key ion channel… read more here.
Keywords: voltage gated; action potential; voltage; cardiac voltage ... See more keywords