Acetylated Signal Transducer and Activator of Transcription 3 Functions as Molecular Adaptor Independent of Transcriptional Activity During Human Cardiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2665
Abstract: Activation of signal transducer and activator of transcription 3 (STAT3) is imperative for mammalian development, specifically cardiogenesis. STAT3 phosphorylation and acetylation are key post‐translational modifications that regulate its transcriptional activity. Significance of such modifications during… read more here.
Keywords: transcription; molecular adaptor; activator; human cardiogenesis ... See more keywords
Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107932
Abstract: Cilia and the intraflagellar transport (IFT) proteins involved in ciliogenesis are associated with congenital heart diseases (CHDs). However, the molecular links between cilia, IFT proteins, and cardiogenesis are yet to be established. Using a combination… read more here.
Keywords: transport complex; complex proteins; effector yap1; intraflagellar transport ... See more keywords
A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.06.017
Abstract: Summary During development, cells respond rapidly to intra- and intercellular signals, which induce signaling cascades regulating the activity of transcription factors at the transcriptional and/or post-translational level. The transcription factor ISL1 plays a key role… read more here.
Keywords: p38 mapk; mapk signaling; cardiogenesis; activity ... See more keywords
FOXK1 regulates Wnt signaling to promote cardiogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular research"
DOI: 10.1093/cvr/cvad054
Abstract: AIMS Congenital heart disease (CHD) is the most common genetic birth defect, which has considerable morbidity and mortality. We focused on deciphering key regulators that govern cardiac progenitors and cardiogenesis. FOXK1 is a forkhead/winged helix… read more here.
Keywords: cardiogenesis; signaling promote; cardiogenesis foxk1; foxk1 ... See more keywords
Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis
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DOI: 10.1371/journal.pone.0183225
Abstract: Cardiac progenitor cells have a limited proliferative capacity. The CREB-binding protein/p300-interacting transactivator, with the Glu/Asp-rich carboxy-terminal domain (Cited) gene family, regulates gene transcription. Increased expression of the Cited4 gene in an adult mouse is associated… read more here.
Keywords: expression; cardiogenesis; cited4 gene; gene ... See more keywords