The Effect of pH on the Structure and Lateral Organization of Cardiolipin in Langmuir Monolayers
Sign Up to like & getrecommendations! Published in 2022 at "Chemphyschem"
DOI: 10.1002/cphc.202200218
Abstract: Abstract Cardiolipin (CL) is a unique phospholipid featuring a dimeric structure. With its four alkyl chains, it has a large hydrophobic region and the charged hydrophilic head group is relatively small. Biological membranes exhibit CL… read more here.
Keywords: organization cardiolipin; structure; lateral organization; cardiolipin ... See more keywords
The critical role of cardiolipin in metazoan differentiation, development, and maturation
Sign Up to like & getrecommendations! Published in 2023 at "Developmental Dynamics"
DOI: 10.1002/dvdy.567
Abstract: Cardiolipins are phospholipids that are central to proper mitochondrial functioning. Because mitochondria play crucial roles in differentiation, development, and maturation, we would also expect cardiolipin to play major roles in these processes. Indeed, cardiolipin has… read more here.
Keywords: role cardiolipin; development maturation; development; cardiolipin ... See more keywords
An improved functional assay in blood spot to diagnose Barth syndrome using the monolysocardiolipin/cardiolipin ratio.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12425
Abstract: Barth syndrome is an X-linked disorder characterized by cardiomyopathy, skeletal myopathy and neutropenia, caused by deleterious variants in TAFAZZIN. This gene encodes a phospholipid-lysophospholipid transacylase that is required for the remodeling of the mitochondrial phospholipid… read more here.
Keywords: barth syndrome; blood spot; cardiolipin;
A simple mechanistic explanation for Barth syndrome and cardiolipin remodeling.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12445
Abstract: Barth syndrome is a multisystem disorder caused by an abnormal metabolism of the mitochondrial lipid cardiolipin. In this review, we discuss physical properties, biosynthesis, membrane assembly, and function of cardiolipin. We hypothesize that cardiolipin reduces… read more here.
Keywords: mechanistic explanation; explanation barth; barth syndrome; cardiolipin ... See more keywords
Cardiolipin interactions with cytochrome c increase tyrosine nitration yields and site-specificity.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108824
Abstract: The interaction between cytochrome c and cardiolipin is a relevant process in the mitochondrial redox homeostasis, playing roles in the mechanism of electron transfer to cytochrome c oxidase and also modulating cytochrome c conformation, reactivity… read more here.
Keywords: nitration; nitration yields; yields site; cardiolipin ... See more keywords
Molecular Dynamics Investigation into the Distribution of Cardiolipin Variants in Flat and Buckled Heterogeneous Bilayers
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1218
Abstract: Cardiolipin is a unique lipid molecule, which has an unusual dimeric structure with a dual-phosphate headgroup and four acyl chains. In most eukaryotic membranes cardiolipin is absent or present only at very low concentrations, however… read more here.
Keywords: molecular dynamics; cardiolipin; distribution cardiolipin; investigation distribution ... See more keywords
Quantitation of Cardiolipin Binding to Human Autophagy (Mitophagy)-Related Atg-8 Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2136
Abstract: The phospholipid cardiolipin (CL) has been proposed to play a role in selective mitochondrial autophagy, or mitophagy. CL externalization to the outer mitochondrial membrane would act as a signal for the human Atg8 ortholog subfamily,… read more here.
Keywords: cardiolipin binding; quantitation cardiolipin; cardiolipin; autophagy mitophagy ... See more keywords
Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia
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DOI: 10.1016/j.celrep.2018.09.057
Abstract: Summary Mitochondria fulfill vital metabolic functions and act as crucial cellular signaling hubs, integrating their metabolic status into the cellular context. Here, we show that defective cardiolipin remodeling, upon loss of the cardiolipin acyl transferase… read more here.
Keywords: cardiolipin remodeling; remodeling dampens; cardiolipin; mitochondrial cardiolipin ... See more keywords
Structure of the complex of cytochrome c with cardiolipin in non-polar environment.
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2018.05.007
Abstract: The complex of mitochondrial protein cytochrome c (CytC) with anionic phospholipid cardiolipin (CL) plays a crucial role in the initiation of apoptosis by catalyzing lipid peroxidation in mitochondrial membranes. In our previous papers, we found… read more here.
Keywords: cyt; cardiolipin; cytochrome; structure complex ... See more keywords
Cytochrome c - cardiolipin interaction leads to the cytochrome c modification and degradation via formation of cardiolipin hydroperoxides
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.251
Abstract: Recently, the complex of cytochrome c (cyt c), a small heme mitochondrial protein, with mitochondria specific lipid cardiolipin (CL) was linked to the control of apoptotic cell death. Under apoptotic conditions cyt c - CL… read more here.
Keywords: degradation; cyt; peroxidase; cardiolipin ... See more keywords
Surface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.02.007
Abstract: The peroxidation of cardiolipins by reactive oxygen species, which is regulated and enhanced by cytochrome c (cyt c), is a critical signaling event in mitochondrial apoptosis. We probe the molecular underpinnings of this mitochondrial death… read more here.
Keywords: binding cardiolipin; triggers cytochrome; cardiolipin nanodomains; cardiolipin ... See more keywords