Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia
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DOI: 10.1016/j.celrep.2018.09.057
Abstract: Summary Mitochondria fulfill vital metabolic functions and act as crucial cellular signaling hubs, integrating their metabolic status into the cellular context. Here, we show that defective cardiolipin remodeling, upon loss of the cardiolipin acyl transferase… read more here.
Keywords: cardiolipin remodeling; remodeling dampens; cardiolipin; mitochondrial cardiolipin ... See more keywords
Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling
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DOI: 10.1126/sciadv.add3855
Abstract: Respiratory complex I is a ~1-MDa proton pump in mitochondria. Its structure has been revealed in great detail, but the structural basis of its assembly, in humans involving at least 15 assembly factors, is essentially… read more here.
Keywords: insights complex; cardiolipin remodeling; assembly function; assembly ... See more keywords
Current Knowledge on the Role of Cardiolipin Remodeling in the Context of Lipid Oxidation and Barth Syndrome
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DOI: 10.3389/fmolb.2022.915301
Abstract: Barth syndrome (BTHS, OMIM 302060) is a genetic disorder caused by variants of the TAFAZZIN gene (G 4.5, OMIM 300394). This debilitating disorder is characterized by cardio- and skeletal myopathy, exercise intolerance, and neutropenia. TAFAZZIN… read more here.
Keywords: current knowledge; oxidation; role; barth syndrome ... See more keywords