Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of Cardiometabolic phenotypes.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvz030
Abstract: Aims To identify genetic variants that have a regulatory impact on circulating miRNAs and to connect genetic risk to blood traits/biomarkers through the circulating miRNAs. Methods and results Leveraging miRNA-Seq data and the 1000 Genomes… read more here.
Keywords: genome wide; circulating mirnas; role several; expression ... See more keywords
P4411Analysis of cardiometabolic traits highlights shared biological pathways
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz745.0815
Abstract: Genome-wide association studies (GWAS) have contributed to a major leap forward in the unravelling of the genetic basis of complex disorders, and identified over 900 genetic loci for blood pressure (BP) regulation, 160 for coronary… read more here.
Keywords: risk; snvs; t2d; nine snvs ... See more keywords
Associations of liver fat content with cardiometabolic phenotypes and outcomes in a multi‐ethnic population: Results from the Dallas Heart Study
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.1111/dom.14905
Abstract: To evaluate the associations between liver fat content and cardiometabolic parameters to explore potential threshold values that define metabolically healthy liver fat content, and to examine the association of liver fat content with cardiovascular events… read more here.
Keywords: fat content; liver fat; associations liver; content cardiometabolic ... See more keywords
Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female-Specific Health Conditions.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Heart Association"
DOI: 10.1161/jaha.121.026561
Abstract: Background Cardiometabolic diseases are highly comorbid, but their relationship with female-specific or overwhelmingly female-predominant health conditions (breast cancer, endometriosis, pregnancy complications) is understudied. This study aimed to estimate the cross-trait genetic overlap and influence of… read more here.
Keywords: health; causal relationships; risk; health conditions ... See more keywords
Association of Vitamin D Receptor Gene Polymorphisms with Cardiometabolic Phenotypes in Hispanics: A Life Course Approach
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15092118
Abstract: The vitamin D receptor (VDR) is vital for maintaining calcium and phosphate balance and regulating bone metabolism. Recent research has suggested that VDR also plays an essential role in metabolic diseases. Previous studies on non-Hispanic… read more here.
Keywords: cardiometabolic phenotypes; vitamin receptor; association vitamin; vdr snps ... See more keywords