In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-13688-z
Abstract: Unlike protein-coding genes, the majority of human long non-coding RNAs (lncRNAs) are considered non-conserved. Although lncRNAs have been shown to function in diverse pathophysiological processes in mice, it remains largely unknown whether human lncRNAs have… read more here.
Keywords: non conserved; cardiometabolic traits; human lncrnas; conserved human ... See more keywords
279GWAS of heart rate in 87,759 Chinese subjects highlighted its genetic correlations with cardiometabolic traits
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Epidemiology"
DOI: 10.1093/ije/dyab168.733
Abstract: Resting heart rate (RHR) has been associated with risks of mortality and multiple chronic diseases. Previous studies, predominantly conducted in Europeans, have reported 91 independent variants associated with RHR and its genetic correlations with several… read more here.
Keywords: rhr; correlations cardiometabolic; cardiometabolic traits; genetic correlations ... See more keywords
BMI and cardiometabolic traits in Japanese: a Mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of epidemiology"
DOI: 10.2188/jea.je20220154
Abstract: BACKGROUND Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated. METHODS We conducted individual-level Mendelian randomization (MR) analyses targeting… read more here.
Keywords: two sample; mendelian randomization; bmi cardiometabolic; sample analyses ... See more keywords
Schizophrenia and cardiometabolic abnormalities: A Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1150458
Abstract: Background: Individuals with a diagnosis of schizophrenia are known to be at high risk of premature mortality due to poor physical health, especially cardiovascular disease, diabetes, and obesity. The reasons for these physical health outcomes… read more here.
Keywords: mendelian randomization; risk; schizophrenia; cardiometabolic traits ... See more keywords
Genetic Variants at the APOE Locus Predict Cardiometabolic Traits and Metabolic Syndrome: A Taiwan Biobank Study
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DOI: 10.3390/genes13081366
Abstract: Several apolipoprotein genes are located at the APOE locus on chromosome 19q13.32. This study explored the genetic determinants of cardiometabolic traits and metabolic syndrome at the APOE locus in a Taiwanese population. A total of… read more here.
Keywords: metabolic syndrome; traits metabolic; taiwan biobank; apoe locus ... See more keywords