Association of coronary microvascular dysfunction and cardiac bridge integrator 1, a cardiomyocyte dysfunction biomarker.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical cardiology"
DOI: 10.1002/clc.23726
Abstract: BACKGROUND Coronary microvascular dysfunction (CMD) is associated with heart failure with preserved ejection fraction (HFpEF); however, pathophysiology is not well described. HYPOTHESIS We hypothesized that CMD in women with suspected ischemia with no obstructive coronary… read more here.
Keywords: microvascular dysfunction; cardiomyocyte; dysfunction; cardiac bridge ... See more keywords
Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Dynamics"
DOI: 10.1002/dvdy.305
Abstract: Zebrafish can regenerate adult cardiac tissue following injuries from ventricular apex amputation, cryoinjury, and cardiomyocyte genetic ablation. Here, we characterize cardiac regeneration from cardiomyocyte chemoptogenetic ablation caused by localized near‐infrared excited photosensitizer‐mediated reactive oxygen species… read more here.
Keywords: heart regenerates; regenerates chemoptogenetic; chemoptogenetic cardiomyocyte; cardiomyocyte depletion ... See more keywords
ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling
Sign Up to like & getrecommendations! Published in 2021 at "STEM CELLS"
DOI: 10.1002/stem.3328
Abstract: ERG1, a potassium ion channel, is essential for cardiac action potential repolarization phase. However, the role of ERG1 for normal development of the heart is poorly understood. Using the rat embryonic stem cells (rESCs) model,… read more here.
Keywords: erg1 plays; essential role; plays essential; role ... See more keywords
Evolution of cardiac pathology in classic Fabry disease: Progressive cardiomyocyte enlargement leads to increased cell death and fibrosis, and correlates with severity of ventricular hypertrophy.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.06.079
Abstract: BACKGROUND Fabry disease, an X-linked lysosomal storage disease, results from deficient α-galactosidase A (α-GalA) activity and the systemic accumulation of α-galactosyl-terminated glycosphingolipids. Two major phenotypes, "Classic" and "Later-Onset", lead to renal failure, and/or cardiac disease,… read more here.
Keywords: disease; pathology; hypertrophy; cardiac pathology ... See more keywords
Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.12.013
Abstract: Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can… read more here.
Keywords: cardiomyocyte relaxation; relaxation contraction; empagliflozin; nitric oxide ... See more keywords
The FGF-AKT pathway is necessary for cardiomyocyte survival for heart regeneration in zebrafish.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.12.019
Abstract: Zebrafish have a remarkable ability to regenerate the myocardium after injury by proliferation of pre-existing cardiomyocytes. Fibroblast growth factor (FGF) signaling is known to play a critical role in zebrafish heart regeneration through promotion of… read more here.
Keywords: heart; fgf signaling; injury; heart regeneration ... See more keywords
Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.01.010
Abstract: The renal-outer-medullary‑potassium (ROMK) channel, mutated in Bartter's syndrome, regulates ion exchange in kidney, but its extra-renal functions remain unknown. Additionally, ROMK was postulated to be the pore-forming subunit of the mitochondrial ATP-sensitive K+ channel (mitoKATP),… read more here.
Keywords: knockout; channel; romk; injury ... See more keywords
Single-cell imaging and transcriptomic analyses of endogenous cardiomyocyte dedifferentiation and cycling
Sign Up to like & getrecommendations! Published in 2019 at "Cell Discovery"
DOI: 10.1038/s41421-019-0095-9
Abstract: While it is recognized that there are low levels of new cardiomyocyte (CM) formation throughout life, the source of these new CM generates much debate. One hypothesis is that these new CMs arise from the… read more here.
Keywords: single cell; cell imaging; cms; dedifferentiation ... See more keywords
Optical-flow based non-invasive analysis of cardiomyocyte contractility
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10094-7
Abstract: Characterization of cardiomyocyte beat patterns is needed for quality control of cells intended for surgical injection as well as to establish phenotypes in disease modeling or toxicity studies. Optical-flow based analysis of videomicroscopic recordings offer… read more here.
Keywords: optical flow; analysis; flow based; contractility ... See more keywords
Assessing fatty acid oxidation flux in rodent cardiomyocyte models
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-19478-9
Abstract: The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements are crucial to investigate early… read more here.
Keywords: fatty acid; fao; cardiomyocyte models; acid oxidation ... See more keywords
Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64621-0
Abstract: Most mouse cardiomyocytes (CMs) become multinucleated shortly after birth via endoreplication and interrupted mitosis, which persists through adulthood. The very closely related inbred mouse strains BALB/cJ and BALB/cByJ differ substantially (6.6% vs. 14.3%) in adult… read more here.
Keywords: nuclear ploidy; cardiomyocyte; balb; balb balb ... See more keywords