MicroRNA‐494 regulates high glucose‐induced cardiomyocyte apoptosis and autophagy by PI3K/AKT/mTOR signalling pathway
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14311
Abstract: Diabetic cardiomyopathy (DCM) is one of the major cardiovascular complications of diabetes. However, the mechanism of DCM is not fully understood. Studies have confirmed that certain microRNAs (miRNAs/miRs) are key regulators of DCM. The aim… read more here.
Keywords: microrna 494; high glucose; cardiomyocyte apoptosis; apoptosis autophagy ... See more keywords
CircTDRD3 aggravates H/R-induced cardiomyocyte apoptosis via targeting miR-4295/TP63 Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23003
Abstract: The myocardial cell injury resulted from Hypoxia/Reoxygenation is the main cause of acute myocardial infarction (AMI). There're many proofs showing the functions of circRNAs in the development of AMI. The study aimed at investigating the… read more here.
Keywords: mir 4295; apoptosis; circtdrd3; tp63 axis ... See more keywords
Short‐term hypoxia upregulated Mas receptor expression to repress the AT1R signaling pathway and attenuate Ang II‐induced cardiomyocyte apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26440
Abstract: Hypertension‐stimulated cardiac hypertrophy and apoptosis play critical roles in the progression of heart failure. Our previous study suggested that hypertensive angiotensin II (Ang II) enhanced insulin‐like growth factor receptor II (IGF‐IIR) expression and cardiomyocyte apoptosis,… read more here.
Keywords: ang induced; apoptosis; signaling pathway; expression ... See more keywords
microRNA‐132 inhibits cardiomyocyte apoptosis and myocardial remodeling in myocardial infarction by targeting IL‐1β
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29175
Abstract: The patients suffering from myocardial infarction (MI) undergo cardiac remodeling with the features of expanded myocardial infarct size and dilated left ventricle. Multiple microRNAs (miRNAs) are emerged as crucial modulators to participate in the remodeling… read more here.
Keywords: mir 132; myocardial remodeling; myocardial infarction; 132 inhibits ... See more keywords
Y‐box protein 1 promotes hypoxia/reoxygenation‐ or ischemia/reperfusion‐induced cardiomyocyte apoptosis via SHP‐1‐dependent STAT3 inactivation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29474
Abstract: Cardiomyocyte apoptosis induced by hypoxia and ischemia plays important roles in heart dysfunction after acute myocardial infarction (AMI). However, the mechanism of apoptosis induction remains unclear. A previous study reported that Y‐box protein 1 (YB1)… read more here.
Keywords: apoptosis; stat3; induced cardiomyocyte; ischemia ... See more keywords
Taurine Prevented Hypoxia Induced Chicken Cardiomyocyte Apoptosis Through the Inhibition of Mitochondrial Pathway Activated by Calpain-1.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8023-5_42
Abstract: Objective To determine whether taurine has protective effects on chicken myocardial apoptosis induced by hypoxic condition through inhibiting calpain-1 derived mitochondrial apoptotic pathway. Methods Chicken primary embryonic myocardial cells were isolated and cultured at 37 °C… read more here.
Keywords: chicken cardiomyocyte; apoptosis; inhibition; cardiomyocyte apoptosis ... See more keywords
GSK3β and MCL-1 mediate cardiomyocyte apoptosis in response to high glucose
Sign Up to like & getrecommendations! Published in 2019 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-019-01798-0
Abstract: Gestational diabetes mellitus is a risk factor for congenital heart defects. Our previous results indicated that a decrease in myocardial cells and an increase in apoptotic cells leads to heart defects under hyperglycemia, but much… read more here.
Keywords: high glucose; cardiomyocyte apoptosis; gsk3 mcl; apoptosis ... See more keywords
PSMB4 inhibits cardiomyocyte apoptosis via activating NF-κB signaling pathway during myocardial ischemia/reperfusion injury.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular histology"
DOI: 10.1007/s10735-021-09977-x
Abstract: Myocardial ischemia/reperfusion (I/R) injury induces cardiomyocyte apoptosis to deteriorate heart function. Thus, how to inhibit cardiomyocyte apoptosis is the focus of recent researches. Proteasome family member PSMB4 (proteasome subunit beta type-4) promotes cell survival. The… read more here.
Keywords: apoptosis; myocardial ischemia; psmb4; expression ... See more keywords
Sevoflurane prevents hypoxia/reoxygenation-induced cardiomyocyte apoptosis by inhibiting PI3KC3-mediated autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Human Cell"
DOI: 10.1007/s13577-018-00230-4
Abstract: Cardiomyocyte apoptosis plays an important role in ischemia/reperfusion (I/R)-induced myocardial injury. Autophagy is suggested to be widely implicated in regulating cell survival and death. The cardioprotection of sevoflurane postconditioning has been long recognized, but the… read more here.
Keywords: hypoxia reoxygenation; induced cardiomyocyte; sevoflurane; cardiomyocyte apoptosis ... See more keywords
Astragalus polysaccharides inhibits cardiomyocyte apoptosis during diabetic cardiomyopathy via the endoplasmic reticulum stress pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.111857
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Traditional Chinese medicine Astragalus membranaceus (Fisch.) Bunge (AM) has been utilized for the treatment of diabetes mellitus and its complications for centuries. Astragalus polysaccharides (APS), the main bioactive ingredient extracted from the root… read more here.
Keywords: stress pathway; astragalus polysaccharides; apoptosis; diabetic cardiomyopathy ... See more keywords
Phosphorylated eEF2 is SUMOylated and induces cardiomyocyte apoptosis during myocardial ischemia reperfusion.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of cardiology"
DOI: 10.1016/j.jjcc.2016.05.020
Abstract: BACKGROUND Cardiomyocyte apoptosis after myocardial ischemia reperfusion (MIR) blocks the recovery of cardiac function during revascularization treatment. Protein synthesis mediated by eukaryotic elongation factor 2 (eEF2) is vital for the recovery of MIR. eEF2 promotes… read more here.
Keywords: eef2; apoptosis; mir; reperfusion ... See more keywords