Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14300
Abstract: Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers… read more here.
Keywords: omecamtiv mecarbil; cardiomyocyte contractile; mecarbil augments; augments cardiomyocyte ... See more keywords
Resveratrol prevents palmitic acid induced cardiomyocyte contractile impairment.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2019-0051
Abstract: Short chain saturated fatty acids, especially palmitic acid (PA), contribute to cardiomyocyte lipotoxicity. This study tests the effects of PA on adult rat cardiomyocyte contractile function and proteins associated with calcium regulating cardiomyocyte contraction and… read more here.
Keywords: palmitic acid; resveratrol; resv; cardiomyocyte contractile ... See more keywords