Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner
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DOI: 10.1007/s10557-021-07299-4
Abstract: β-Adrenergic receptors (βAR) are essential targets for the treatment of heart failure (HF); however, chronic use of βAR agonists as positive inotropes to increase contractility in a Gs protein-dependent manner is associated with increased mortality.… read more here.
Keywords: icl1 mediated; contractility; icl1; cardiomyocyte contractility ... See more keywords
Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging
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DOI: 10.1155/2020/8141307
Abstract: Globally, cardiovascular diseases are the leading cause of death in the aging population. While the clinical pathology of the aging heart is thoroughly characterized, underlying molecular mechanisms are still insufficiently clarified. The aim of the… read more here.
Keywords: premature senescence; cardiomyocyte contractility; contractility autophagy; senescence ... See more keywords