Polycaprolactone‐co‐polylactic acid nanofiber scaffold in combination with 5‐azacytidine and transforming growth factor‐β to induce cardiomyocyte differentiation of adipose‐derived mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3728
Abstract: Adipose‐derived mesenchymal stem cells (Ad‐MSCs) are promising candidates for cardiac repair/regeneration. The application of copolymer nanoscaffolds has received great attention in tissue engineering to support differentiation and functional tissue organization toward effective tissue regeneration. The… read more here.
Keywords: pcl pla; azacytidine; cardiomyocyte differentiation; adipose derived ... See more keywords
Cardiomyocyte Differentiation Promotes Cell Survival During Nicotinamide Phosphoribosyltransferase Inhibition Through Increased Maintenance of Cellular Energy Stores
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.16-0151
Abstract: To address concerns regarding the tumorigenic potential of undifferentiated human pluripotent stem cells (hPSC) that may remain after in vitro differentiation and ultimately limit the broad use of hPSC‐derivatives for therapeutics, we recently described a… read more here.
Keywords: medicine; inhibition; hpsc; differentiation ... See more keywords
Cpmer: A new conserved eEF1A2-binding partner that regulates Eomes translation and cardiomyocyte differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cell reports"
DOI: 10.1016/j.stemcr.2022.03.006
Abstract: Previous studies have shown that eukaryotic elongation factor 1A2 (eEF1A2) serves as an essential heart-specific translation elongation element and that its mutation or knockout delays heart development and causes congenital heart disease and death among… read more here.
Keywords: eomes translation; differentiation; heart; cardiomyocyte differentiation ... See more keywords
Efficiency Comparison of Direct Reprogramming CD34+ Cells into Cardiomyocytes Using Cardiomyocyte Differentiation Medium vs MicroRNA-1.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular reprogramming"
DOI: 10.1089/cell.2021.0075
Abstract: The development of a direct reprogramming method to provide cell availability for regenerative therapy has led to a lot of studies. However, the search for appropriate cell sources and methods is still being carried out… read more here.
Keywords: cardiomyocyte differentiation; direct reprogramming; cd34 cells; differentiation medium ... See more keywords
Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity
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DOI: 10.1155/2018/8608327
Abstract: Cardiac development is a dynamic process and sensitive to environmental chemicals. Triclosan is widely used as an antibacterial agent and reported to transport across the placenta and affect embryonic development. Here, we used human embryonic… read more here.
Keywords: differentiation toxicity; differentiation; transcriptome dna; development ... See more keywords
Improved Efficiency of Cardiomyocyte-Like Cell Differentiation from Rat Adipose Tissue-Derived Mesenchymal Stem Cells with a Directed Differentiation Protocol
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells International"
DOI: 10.1155/2019/8940365
Abstract: Cell-based therapy has become a resource for the treatment of cardiovascular diseases; however, there are some conundrums to achieve. In vitro cardiomyocyte generation could be a solution for scaling options in clinical applications. Variability on… read more here.
Keywords: differentiation protocol; differentiation; efficiency; cardiomyocyte differentiation ... See more keywords
Role of Signaling Pathways during Cardiomyocyte Differentiation of Mesenchymal Stem Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiology"
DOI: 10.1159/000521313
Abstract: Multipotent stem cells, including mesenchymal stem cells (MSCs), represent a promising source to be used by regenerative medicine. They are capable of performing myogenic, chondrogenic, osteogenic and adipogenic differentiation. Also, MSCs are characterized by the… read more here.
Keywords: signaling pathways; differentiation; cardiomyocyte differentiation; stem cells ... See more keywords
Abstract 722: Unveiling Ccbe1 Role as a Modulator of Cardiomyocyte Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.722
Abstract: Chronic heart failure is a major unmet clinical need arising from the loss of viable and functional cardiac muscle, representing a major cause of mortality worldwide. There is a need to identify key molecules and… read more here.
Keywords: cardiac commitment; abstract 722; differentiation; ccbe1 ... See more keywords
Practical adoption of state-of-the-art hiPSC-cardiomyocyte differentiation techniques
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DOI: 10.1371/journal.pone.0230001
Abstract: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes are a valuable resource for cardiac therapeutic development; however, generation of these cells in large numbers and high purity is a limitation in widespread adoption. Here, design of… read more here.
Keywords: hipsc; adoption; differentiation; hipsc cardiomyocyte ... See more keywords
MiR-301a promotes embryonic stem cell differentiation to cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Stem Cells"
DOI: 10.4252/wjsc.v11.i12.1130
Abstract: BACKGROUND Cardiovascular disease is the leading cause of death worldwide. Tissue repair after pathological injury in the heart remains a major challenge due to the limited regenerative ability of cardiomyocytes in adults. Stem cell-derived cardiomyocytes… read more here.
Keywords: mir 301a; mes cells; stem cell; differentiation ... See more keywords
Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.16312
Abstract: Rictor is a key regulatory/structural subunit of the mammalian target of rapamycin complex 2 (mTORC2) and is required for phosphorylation of Akt at serine 473. It plays an important role in cell survival, actin cytoskeleton… read more here.
Keywords: rictor; rictor mtorc2; differentiation; cardiomyocyte differentiation ... See more keywords