Hierarchical Topography with Tunable Micro‐ and Nanoarchitectonics for Highly Enhanced Cardiomyocyte Maturation via Multi‐Scale Mechanotransduction
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202371
Abstract: Enhancing cardiomyocyte (CM) maturation by topographical cues is a critical issue in cardiac tissue engineering. Thus far, single‐scale topographies with a broad range of feature shapes and dimensions have been utilized including grooves, pillars, and… read more here.
Keywords: maturation; scale; cardiomyocyte maturation; hierarchical topography ... See more keywords
Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2833
Abstract: The process by which committed precursors mature into cardiomyocytes is poorly understood. We found that TLR3 inhibition blocked cardiomyocyte maturation; precursor cells committed to the cardiomyocyte lineage failed to express maturation genes and sarcomeres did… read more here.
Keywords: mature cardiomyocytes; cardiomyocyte maturation; factor kappa; maturation ... See more keywords
Epigenetic Priming of Human Pluripotent Stem Cell‐Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation
Sign Up to like & getrecommendations! Published in 2019 at "STEM CELLS"
DOI: 10.1002/stem.3021
Abstract: Human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) exhibit a fetal phenotype that limits in vitro and therapeutic applications. Strategies to promote cardiomyocyte maturation have focused interventions on differentiated hPSC‐CMs, but this study tests priming of early… read more here.
Keywords: hpsc cms; cardiomyocyte maturation; cardiac progenitor; pic ... See more keywords
Proteolysis regulates cardiomyocyte maturation and tissue integration
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14495
Abstract: Tissue integrity is critical for organ formation and function. During heart development, cardiomyocytes differentiate and integrate to form a coherent tissue that contracts synchronously. However, the molecular mechanisms regulating cardiac tissue integrity are poorly understood.… read more here.
Keywords: proteolysis; cardiomyocyte maturation; regulates cardiomyocyte; tissue ... See more keywords
AP-1 activation mediates postnatal cardiomyocyte maturation.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac088
Abstract: AIMS Postnatal maturation of mammalian cardiomyocytes proceeds rapidly after birth, with most of the myocytes exiting cell cycle, becoming binucleated, and adopting oxidative phosphorylation as the primary metabolic route. The triggers and transcriptional programs regulating… read more here.
Keywords: maturation; cardiomyocyte maturation; rna seq; heart ... See more keywords
Fibrinogen‐like protein 2 contributes to normal murine cardiomyocyte maturation and heart development
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Physiology"
DOI: 10.1113/ep089450
Abstract: What is the central question of this study? What is the role of fibrinogen‐like protein 2 (FGL2) in murine cardiomyocyte maturation? What is the main finding and its importance? This is the first study showing… read more here.
Keywords: fibrinogen like; like protein; cardiomyocyte; cardiomyocyte maturation ... See more keywords
Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.abo6718
Abstract: Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proliferation… read more here.
Keywords: calcium; maturation; cardiomyocyte maturation; cardiac dyad ... See more keywords
Abstract 15541: Novel Molecular Entity for Effective Cardiac Regeneration: 5’ppp Microrna Induces Reprogramming and Accelerates Cardiomyocyte Maturation
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.15541
Abstract: We have shown that miR combo directly reprograms fibroblasts into cardiomyocytes. However, both in vitro and in vivo, the generated cardiomyocytes are immature. Recently, we discovered that cardiomyocyte maturation is enhanced by NFkB activation. While… read more here.
Keywords: maturation; molecular entity; mir combo; cardiomyocyte maturation ... See more keywords
Sympathetic Neurons Regulate Cardiomyocyte Maturation in Culture
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.850645
Abstract: Embryos devoid of autonomic innervation suffer sudden cardiac death. However, whether autonomic neurons have a role in heart development is poorly understood. To investigate if sympathetic neurons impact cardiomyocyte maturation, we co-cultured phenotypically immature cardiomyocytes… read more here.
Keywords: neurons regulate; maturation; maturation culture; regulate cardiomyocyte ... See more keywords
Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.864516
Abstract: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is a key player in cardiomyocyte calcium handling and also a classic target in the gene therapy for heart failure. SERCA2 expression dramatically increases during cardiomyocyte maturation in the… read more here.
Keywords: endoplasmic reticulum; calcium; maturation; role ... See more keywords
Transcriptional Regulation of Postnatal Cardiomyocyte Maturation and Regeneration
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063288
Abstract: During the postnatal period, mammalian cardiomyocytes undergo numerous maturational changes associated with increased cardiac function and output, including hypertrophic growth, cell cycle exit, sarcomeric protein isoform switching, and mitochondrial maturation. These changes come at the… read more here.
Keywords: maturation; postnatal period; cardiomyocyte maturation; transcriptional regulation ... See more keywords