Phases and Mechanisms of Embryonic Cardiomyocyte Proliferation and Ventricular Wall Morphogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Cardiology"
DOI: 10.1007/s00246-019-02164-6
Abstract: If viewed as a movie, heart morphogenesis appears to unfold in a continuous and seamless manner. At the mechanistic level, however, a series of discreet and separable processes sequentially underlie heart development. This is evident… read more here.
Keywords: proliferation ventricular; ventricular wall; cardiomyocyte proliferation; morphogenesis ... See more keywords
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.05.005
Abstract: Summary Loss of functional cardiomyocytes is a major determinant of heart failure after myocardial infarction. Previous high throughput screening studies have identified a few microRNAs (miRNAs) that can induce cardiomyocyte proliferation and stimulate cardiac regeneration… read more here.
Keywords: common regulatory; mir 199a; cardiomyocyte proliferation; proliferation ... See more keywords
PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.06.065
Abstract: Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types. The role of PDGFR signaling in heart regeneration is still unknown. We find that PDGFR-β signaling… read more here.
Keywords: heart regeneration; regeneration; pdgfr signaling; cardiomyocyte proliferation ... See more keywords
Signals for cardiomyocyte proliferation during zebrafish heart regeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in physiology"
DOI: 10.1016/j.cophys.2020.02.002
Abstract: The common laboratory zebrafish can regenerate functional cardiac muscle after cataclysmic damage or loss, by activating programs that direct the division of spared cardiomyocytes. Heart regeneration is not a linear series of molecular steps and… read more here.
Keywords: proliferation zebrafish; heart regeneration; heart; cardiomyocyte proliferation ... See more keywords
Misoprostol attenuates neonatal cardiomyocyte proliferation through Bnip3, perinuclear calcium signaling, and inhibition of glycolysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.06.010
Abstract: Systemic hypoxia resulting from preterm birth, altered lung development, and cyanotic congenital heart disease is known to impede the regulatory and developmental pathways in the neonatal heart. While the molecular mechanisms are still unknown, hypoxia… read more here.
Keywords: cardiomyocyte proliferation; misoprostol; proliferation; bnip3 ... See more keywords
Cardiac regeneration: Cardiomyocyte proliferation: a variable genetic trait?
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cardiology"
DOI: 10.1038/nrcardio.2017.133
Abstract: Frequency of mononucleated diploid cardiomyocytes underlies natural variation in heart regeneration. Nat. Genet. http://dx.doi.org/ 10.1038/ng.3929 (2017) MNDCM frequency is a good surrogate to predict improved postinjury outcome Reprinted from Patterson, M. et al. Frequency of… read more here.
Keywords: regeneration cardiomyocyte; cardiac regeneration; regeneration; cardiomyocyte proliferation ... See more keywords
Metabolic Determinants of Cardiomyocyte Proliferation
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells"
DOI: 10.1093/stmcls/sxac016
Abstract: Abstract The adult mammalian heart is recalcitrant to regeneration after injury, in part due to the postmitotic nature of cardiomyocytes. Accumulating evidence suggests that cardiomyocyte proliferation in fetal or neonatal mammals and in regenerative non-mammalian… read more here.
Keywords: proliferation; metabolic determinants; cardiomyocyte proliferation; determinants cardiomyocyte ... See more keywords
LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17311
Abstract: The neonatal heart can efficiently regenerate within a short period after birth, whereas the adult mammalian heart has extremely limited capacity to regenerate. The molecular mechanisms underlying neonatal heart regeneration remain elusive. Here, we revealed… read more here.
Keywords: heart; cardiomyocyte proliferation; neonatal heart; heart regeneration ... See more keywords
Long Noncoding RNA CPR (Cardiomyocyte Proliferation Regulator) Regulates Cardiomyocyte Proliferation and Cardiac Repair.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.118.035832
Abstract: BACKGROUND The adult mammalian cardiomyocytes lose their proliferative capacity, which is responsible for cardiac dysfunction and heart failure following injury. The molecular mechanisms underlying the attenuation of adult cardiomyocyte proliferation remain largely unknown. Because long… read more here.
Keywords: cpr; proliferation cardiac; cardiomyocyte proliferation; cardiac repair ... See more keywords
TT-10-loaded nanoparticles promote cardiomyocyte proliferation and cardiac repair in a mouse model of myocardial infarction.
Sign Up to like & getrecommendations! Published in 2021 at "JCI insight"
DOI: 10.1172/jci.insight.151987
Abstract: The meager regenerative capacity of adult mammalian hearts appears to be driven by the proliferation of endogenous cardiomyocytes; thus, strategies targeting mechanisms of cardiomyocyte cell cycle regulation, such as the Hippo/Yes-associated protein (Hippo/Yap) pathway, could… read more here.
Keywords: week; cardiomyocyte proliferation; proliferation; nanoparticles promote ... See more keywords
Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00042
Abstract: Cardiomyocyte proliferation accounts for the increase of cardiac muscle during fetal mammalian heart development. Shortly after birth, cardiomyocyte transits from hyperplasia to hypertrophic growth. Here, we have investigated the role of fatty acid β-oxidation in… read more here.
Keywords: cardiomyocyte; fatty acid; cardiomyocyte proliferation; acid oxidation ... See more keywords