LncRNA Rian reduces cardiomyocyte pyroptosis and alleviates myocardial ischemia–reperfusion injury by regulating by the miR-17-5p/CCND1 axis
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DOI: 10.1038/s41440-022-00884-6
Abstract: Myocardial ischemia–reperfusion injury (MIRI) is a pathological process characterized by cardiomyocyte death. Long noncoding RNAs (lncRNAs) have been shown to be dysregulated in the course of MIRI. Accordingly, the current study investigated the mechanism of… read more here.
Keywords: miri; lncrna rian; pyroptosis; cardiomyocyte pyroptosis ... See more keywords
Mechanism of miR-126 in hypoxia-reoxygenation-induced cardiomyocyte pyroptosis by regulating HMGB1 and NLRP3 inflammasome
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DOI: 10.1080/08923973.2022.2054819
Abstract: Abstract Objective Pyroptosis refers to the programmed cell death. This study evaluated the mechanism of miR-126 in hypoxia-reoxygenation (HR)-induced cardiomyocyte pyroptosis. Methods The HR rat cardiomyocyte models were established. The cell viability, cytotoxicity, and levels… read more here.
Keywords: hmgb1; pyroptosis; cardiomyocyte pyroptosis; mir 126 ... See more keywords
miR-15b-5p REGULATES THE NLRP3 INFLAMMASOME SIGNAL THROUGH TARGETING SIRT3 TO REGULATE HYPOXIA/REOXYGENATION-INDUCED CARDIOMYOCYTE PYROPTOSIS PROCESS
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DOI: 10.1097/shk.0000000000001961
Abstract: ABSTRACT Hypoxia/reoxygenation (H/R) induces pyroptosis in the setting of acute myocardial infarction (AMI). Previous studies have shown that the expression of the miR-15 family is stimulated in myocardial ischemia–reperfusion injury or H/R-induced cardiomyocyte injury, and… read more here.
Keywords: mir 15b; pyroptosis; cardiomyocyte pyroptosis; injury ... See more keywords
Echinacoside inhibited cardiomyocyte pyroptosis and improved heart function of HF rats induced by isoproterenol via suppressing NADPH/ROS/ER stress
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DOI: 10.1111/jcmm.17564
Abstract: Prevalence of heart failure (HF) continues to rise over time and is a global difficult problem; new drug targets are urgently needed. In recent years, pyroptosis is confirmed to promote cardiac remodelling and HF. Echinacoside… read more here.
Keywords: improved heart; pyroptosis; heart function; cardiomyocyte pyroptosis ... See more keywords
Retinol-Binding Protein 4 Promotes Cardiac Injury After Myocardial Infarction Via Inducing Cardiomyocyte Pyroptosis Through an Interaction With NLRP3.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Heart Association"
DOI: 10.1161/jaha.121.022011
Abstract: Background Acute myocardial infarction (AMI) is one of the leading causes of cardiovascular morbidity and mortality worldwide. Pyroptosis is a form of inflammatory cell death that plays a major role in the development and progression… read more here.
Keywords: pyroptosis; rbp4; cardiomyocyte pyroptosis; cardiac injury ... See more keywords
Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.906548
Abstract: Diabetic cardiomyopathy (DCM) is one of the common complications of diabetic patients, which can induce myocardial hypertrophy, cardiac fibrosis, and heart failure. Growing evidence has shown that the occurrence and development of DCM are accompanied… read more here.
Keywords: pyroptosis; cvb; cardiomyocyte pyroptosis; inhibiting cardiomyocyte ... See more keywords