Dexmedetomidine protects cardiomyocytes against hypoxia/reoxygenation injury via multiple mechanisms.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24119
Abstract: BACKGROUND Myocardial infarction (MI) is a serious cardiovascular disease associated with myocardial ischemia/reperfusion (I/R) injury. Dexmedetomidine (Dex), an α2-adrenoceptor agonist, has been reported to protect against I/R injury. We examined the cardioprotective effects of Dex… read more here.
Keywords: hypoxia reoxygenation; injury; measured using; dex ... See more keywords
Exosomes as a messager to regulate the crosstalk between macrophages and cardiomyocytes under hypoxia conditions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17162
Abstract: Recent studies have confirmed that cardiomyocyte‐derived exosomes have many pivotal biological functions, like influencing the progress of coronary artery disease via modulating macrophage phenotypes. However, the mechanisms underlying the crosstalk between cardiomyocytes and macrophages have… read more here.
Keywords: cardiomyocytes hypoxia; crosstalk macrophages; regulate crosstalk; crosstalk ... See more keywords
Astragaloside IV Protects Rat Cardiomyocytes from Hypoxia-Induced Injury by Down-Regulation of miR-23a and miR-92a
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DOI: 10.1159/000493827
Abstract: Background/Aims: Astragaloside IV (AS-IV), a traditional Chinese medicine isolated from Astragalus membranaceus, has been shown to exert cardioprotective effect previously. This study aimed to reveal the effects of AS-IV on hypoxia-injured cardiomyocyte. Methods: H9c2 cells… read more here.
Keywords: hypoxia induced; 23a mir; mir 23a; mir 92a ... See more keywords
Regulation of a Novel CircTRRAP/miR-761/MAP3K2 CeRNA Cascade in Inflammation, Apoptosis, and Oxidative Stress in Human AC16 Cardiomyocytes under Hypoxia Conditions.
Sign Up to like & getrecommendations! Published in 2023 at "International heart journal"
DOI: 10.1536/ihj.22-624
Abstract: Emerging evidence uncovers the important involvement of circular RNAs (circRNAs) in the dysfunction of cardiomyocytes under hypoxia conditions. However, no studies proved whether circTRRAP (hsa_circ_0081241) can participate in cardiomyocyte injury evoked by hypoxia.A qRT-PCR or… read more here.
Keywords: cardiomyocytes hypoxia; map3k2; circtrrap mir; mir 761 ... See more keywords