VEGF-B electrotransfer mediated gene therapy induces cardiomyogenesis in a rat model of cardiac ischemia.
Sign Up to like & getrecommendations! Published in 2018 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2018.07.007
Abstract: Atherosclerosis induced myocardial infarction (MI) continues to be a major public health concern. Regenerative therapies that restore cardiac muscle cells are largely absent. The rate of cardiomyogenesis in adults is insufficient to compensate for MI… read more here.
Keywords: gene; rat model; gene therapy; cardiomyogenesis ... See more keywords
Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Biology"
DOI: 10.1016/j.ydbio.2017.11.017
Abstract: The transcription factors GATA4, GATA5 and GATA6 are important regulators of heart muscle differentiation (cardiomyogenesis), which function in a partially redundant manner. We identified genes specifically regulated by individual cardiogenic GATA factors in a genome-wide… read more here.
Keywords: genome wide; cardiomyogenesis; sox7 sox18; wide transcriptomics ... See more keywords
lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.121.056850
Abstract: Background: The heart grows in response to pathological and physiological stimuli. The former often precedes cardiomyocyte loss and heart failure; the latter paradoxically protects the heart and enhances cardiomyogenesis. The mechanisms underlying these differences remain… read more here.
Keywords: hypertrophy; lncexact1 dchs2; cardiac; dchs2 ... See more keywords
miR-6087 Might Regulate Cell Cycle–Related mRNAs During Cardiomyogenesis of hESCs
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DOI: 10.1177/11779322231161918
Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that act as negative regulators of gene expression at the post-transcriptional level, promoting mRNA degradation or translation repression. Despite the well-described presence of miRNAs in various human tissues, there… read more here.
Keywords: cell cycle; hescs; mir 6087; mir ... See more keywords
Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.01357
Abstract: Extracts from the leaves and flowers of Crataegus spp. (i.e., hawthorn species) have been traditionally used with documented preclinical and clinical activities in cardiovascular medicine. Based on reported positive effects on heart muscle after ischemic… read more here.
Keywords: cardiomyogenesis; pharmacology; crataegus extract; stem ... See more keywords