Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention.
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DOI: 10.1016/j.molmed.2019.06.005
Abstract: Hypertrophic cardiomyopathy (HCM) is a prevalent and complex cardiovascular disease where cardiac dysfunction often associates with mutations in sarcomeric genes. Various models based on tissue explants, isolated cardiomyocytes, skinned myofibrils, and purified actin/myosin preparations have… read more here.
Keywords: cardiomyopathy mechanistic; modeling hypertrophic; hypertrophic cardiomyopathy; pharmacological intervention ... See more keywords