Nitrite-Nitric Oxide Signaling and Cardioprotection.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-55330-6_18
Abstract: Cardioprotective strategies to prevent damage to mitochondria in acute myocardial infarction are warranted to reduce lethal myocardial ischemia/reperfusion (I/R) injury. Mitochondrial antagonists in I/R are reactive oxygen species (ROS), deteriorated calcium signaling, permeabilization of the… read more here.
Keywords: nitrite nitric; oxide signaling; signaling cardioprotection; biology ... See more keywords
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action
Sign Up to like & getrecommendations! Published in 2021 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-021-00893-5
Abstract: Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new therapeutic interventions are still needed to protect the heart against… read more here.
Keywords: improving preclinical; cardioprotective interventions; preclinical assessment; cardioprotection ... See more keywords
Angiotensin (1–7) facilitates cardioprotection of ischemic preconditioning on ischemia–reperfusion-challenged rat heart
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2958-4
Abstract: Ischemic preconditioning (IPC) is one of the most promising strategies used to protect the myocardium from ischemia–reperfusion injury. Ang (1–7) exhibits cardioprotective activity; however, its therapeutic potential on IPC-induced cardioprotection has not been reported in… read more here.
Keywords: ipc; reperfusion challenged; reperfusion; ischemia reperfusion ... See more keywords
Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.09.086
Abstract: Many treatments have been identified that confer robust cardioprotection in experimental animal models of acute ischemia and reperfusion injury. However, translation of these cardioprotective therapies into the clinical setting of acute myocardial infarction (AMI) for… read more here.
Keywords: ischemia reperfusion; reperfusion injury; cardioprotection; multitarget ... See more keywords
Oxytocin mediated cardioprotection is independent of coronary endothelial function in rats
Sign Up to like & getrecommendations! Published in 2020 at "Peptides"
DOI: 10.1016/j.peptides.2020.170333
Abstract: The cardioprotective effect of oxytocin (OT) has been well established. However, there are no related studies on the role of endothelia in oxytocin-induced cardioprotection. Endothelial dysfunction (ED) model was established by injection of 0.01% Triton… read more here.
Keywords: endothelial function; microscopy; coronary endothelial; injury ... See more keywords
Cardioprotection Effects of LPTC-5 Involve Mitochondrial Protection and Dynamics
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.8b02441
Abstract: We recently designed and synthesized a series of novel levodopa–peptide–TEMPO conjugates (LPTCs). Among these compounds, LPTC-5 possesses both free-radical scavenging potential and mitochondrial fusion-promoting activity. The free-radical scavenging capacity of LPTC-5 was confirmed using a… read more here.
Keywords: lptc involve; cardioprotection; effects lptc; lptc ... See more keywords
Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00891-z
Abstract: Myocardial infarction is the leading cause of death worldwide. Restoration of blood flow rescues myocardium but also causes ischemia-reperfusion injury. Here, we show that in a mouse model of chronic neuropathic pain, ischemia-reperfusion injury following… read more here.
Keywords: paraventricular thalamus; neuropathic pain; mouse model; cardioprotection ... See more keywords
Cardioprotection by limb remote ischemic preconditioning in rats: discrepancy between meta-analysis and a three-center in vivo study
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvac066.070
Abstract: Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Heart Program funded by the National Research, Development and Innovation Office of Hungary Higher Education Institutional Excellence Programme of the Ministry… read more here.
Keywords: ripc; cardioprotection; meta analysis; study ... See more keywords
Innate immunity as a target for acute cardioprotection.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvy304
Abstract: Acute obstruction of a coronary artery causes myocardial ischaemia and if prolonged, may result in an ST-segment elevation myocardial infarction (STEMI). First-line treatment involves rapid reperfusion. However, a highly dynamic and co-ordinated inflammatory response is… read more here.
Keywords: target acute; innate immunity; cardioprotection; immunity target ... See more keywords
Hypothermic, oxygenated perfusion (HOPE) provides cardioprotection via succinate oxidation prior to normothermic perfusion in a rat model of donation after circulatory death (DCD)
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Transplantation"
DOI: 10.1111/ajt.16258
Abstract: In donation after circulatory death (DCD), cardiac grafts are subjected to warm ischemia in situ, prior to a brief period of cold, static storage (CSS) at procurement, and ex situ, normothermic, machine perfusion (NMP) for… read more here.
Keywords: oxidation; perfusion; donation circulatory; succinate ... See more keywords
Co‐morbidities and co‐medications as confounders of cardioprotection—Does it matter in the clinical setting?
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14839
Abstract: The translation of cardioprotection from robust experimental evidence to beneficial clinical outcome for patients suffering acute myocardial infarction or undergoing cardiovascular surgery has been largely disappointing. The present review attempts to critically analyse the evidence… read more here.
Keywords: confounders cardioprotection; morbidities medications; myocardial infarction; evidence ... See more keywords