An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors
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DOI: 10.3390/ijms23073651
Abstract: Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic regulation in diabetes. In addition to their glucose-lowering effects, SGLT2 inhibitors prevent… read more here.
Keywords: protective mechanisms; overview cardiorenal; mechanisms sglt2; cardiorenal protective ... See more keywords
Enhanced Cardiorenal Protective Effects of Combining SGLT2 Inhibition, Endothelin Receptor Antagonism and RAS Blockade in Type 2 Diabetic Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112823
Abstract: Treatments with sodium–glucose 2 cotransporter inhibitors (SGLT2i) or endothelin receptor antagonists (ERA) have shown cardiorenal protective effects. The present study aimed to evaluate the cardiorenal beneficial effects of the combination of SGLT2i and ERA on… read more here.
Keywords: protective effects; type diabetic; diabetic mice; mice ... See more keywords