The role of β‐adrenergic receptors and p38MAPK signaling pathways in physiological processes of cardiosphere‐derived cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26292
Abstract: The effects of β adrenergic receptors (β‐ARs) and p38 mitogen‐activated protein kinases (MAPK) pathways on cardiosphere‐derived cells (CDCs) are largely unknown. This study aimed to investigate the roles of β‐ARs and p38MAPK pathways on the… read more here.
Keywords: p38mapk signaling; signaling pathways; adrenergic receptors; group ... See more keywords
Biodistribution of unmodified cardiosphere-derived cell extracellular vesicles using single RNA tracing.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of extracellular vesicles"
DOI: 10.1002/jev2.12178
Abstract: Extracellular vesicles (EVs) are potent signalling mediators. Although interest in EV translation is ever-increasing, development efforts are hampered by the inability to reliably assess the uptake of EVs and their RNA cargo. Here, we establish… read more here.
Keywords: extracellular vesicles; derived cell; cardiosphere derived; biodistribution unmodified ... See more keywords
Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-022-00913-y
Abstract: Cardiosphere-derived cells (CDCs) generated from human cardiac biopsies have been shown to have disease-modifying bioactivity in clinical trials. Paradoxically, CDCs’ cellular origin in the heart remains elusive. We studied the molecular identity of CDCs using… read more here.
Keywords: cells cdcs; cardiosphere derived; molecular identity; cell ... See more keywords
Characterization of encapsulated porcine Cardiosphere-Derived Cells embedded in 3D alginate matrices.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120454
Abstract: Myocardial infarction is caused by an interruption of coronary blood flow, leading to one of the main death causes worldwide. Current therapeutic approaches are palliative and not able to solve the loss of cardiac tissue.… read more here.
Keywords: alginate; characterization encapsulated; cdcs; cardiosphere derived ... See more keywords
Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice.
Sign Up to like & getrecommendations! Published in 2021 at "European heart journal"
DOI: 10.1093/eurheartj/ehab419
Abstract: AIMS Arrhythmogenic cardiomyopathy (ACM) is characterized by progressive loss of cardiomyocytes, and fibrofatty tissue replacement. Extracellular vesicles (EVs) secreted by cardiosphere-derived cells, immortalized, and engineered to express high levels of β-catenin, exert anti-inflammatory, and anti-fibrotic… read more here.
Keywords: extracellular vesicles; cardiosphere derived; dsg2mt mice; mice ... See more keywords
The Immunomodulatory Signature of Extracellular Vesicles From Cardiosphere-Derived Cells: A Proteomic and miRNA Profiling
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00321
Abstract: Experimental data demonstrated that the regenerative potential and immunomodulatory capacity of cardiosphere-derived cells (CDCs) is mediated by paracrine mechanisms. In this process, extracellular vesicles derived from CDCs (EV-CDCs) are key mediators of their therapeutic effect.… read more here.
Keywords: extracellular vesicles; cdcs; immunomodulatory signature; signature extracellular ... See more keywords