Endogenous cardiotonic steroids and cardiovascular disease, where to next?
Sign Up to like & getrecommendations! Published in 2019 at "Cell Calcium"
DOI: 10.1016/j.ceca.2019.102156
Abstract: Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more… read more here.
Keywords: endogenous cardiotonic; disease; disease next; cardiotonic steroids ... See more keywords
Quantitative proteomic analysis reveals high interference on protein expression of H9c2 cells activated with glucose and cardiotonic steroids.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.103536
Abstract: In recent decades, the incidence of death and morbidity due to diabetes has increased worldwide, causing a high social and economic impact. Diabetes is a major cause of blindness, kidney failure, heart attack, stroke and… read more here.
Keywords: protein; h9c2 cells; cells activated; expression ... See more keywords
Probing the stereoselectivity of OleD-catalyzed glycosylation of cardiotonic steroids
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c7ra11979h
Abstract: The glycosyltransferase OleD variant as a catalyst for the glycosylation of four pairs of epimers of cardiotonic steroids (CTS) are assessed. The results of this study demonstrated that the OleD-catalyze glycosylation of CTS is significantly… read more here.
Keywords: oled catalyzed; probing stereoselectivity; catalyzed glycosylation; stereoselectivity oled ... See more keywords
A real-time PCR method to genotype mutant mouse models with altered affinity for cardiotonic steroids on the Na,K-ATPase
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267348
Abstract: The highly conserved, cardiotonic steroid binding site (also termed ouabain binding site) on the primary α subunit of Na,K-ATPase plays a receptor signaling role in a range of vital cell processes and is a therapeutic… read more here.
Keywords: cardiotonic steroids; real time; altered affinity; pcr ... See more keywords
Quantification of Cardiotonic Steroids Potentially Regulated by Paraoxonase 3 in a Rat Model of Chronic Kidney Disease Using UHPLC-Orbitrap-MS
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113565
Abstract: Endogenous cardiotonic steroids (CTSs), such as telocinobufagin (TCB) and marinobufagin (MBG) contain a lactone moiety critical to their binding and signaling through the Na+/K+-ATPase. Their concentrations elevate in response to sodium intake and under volume-expanded… read more here.
Keywords: cardiotonic steroids; model chronic; chronic kidney; rat model ... See more keywords