Machine learning based radiomics model to predict radiotherapy induced cardiotoxicity in breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.14614
Abstract: Abstract Purpose Cardiotoxicity is one of the major concerns in breast cancer treatment, significantly affecting patient outcomes. To improve the likelihood of favorable outcomes for breast cancer survivors, it is essential to carefully balance the… read more here.
Keywords: breast cancer; treatment; cardiotoxicity; machine learning ... See more keywords
Multiscale Anisotropic Scaffold Integrating 3D Printing and Electrospinning Techniques as a Heart-on-a-chip Platform for Evaluating Drug-induced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300719
Abstract: Cardiac safety assessments are significant in drug discovery, as drug-induced cardiotoxicity is the primary cause of drug attrition. Despite heart-on-a-chip technology having become an increasingly popular tool for evaluating drug-induced cardiotoxicity, its development remains a… read more here.
Keywords: drug induced; induced cardiotoxicity; cardiotoxicity; drug ... See more keywords
Investigating and Resolving Cardiotoxicity Induced by COVID‐19 Treatments using Human Pluripotent Stem Cell‐Derived Cardiomyocytes and Engineered Heart Tissues
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203388
Abstract: Coronavirus disease 2019 continues to spread worldwide. Given the urgent need for effective treatments, many clinical trials are ongoing through repurposing approved drugs. However, clinical data regarding the cardiotoxicity of these drugs are limited. Human… read more here.
Keywords: cell; stem cell; pluripotent stem; human pluripotent ... See more keywords
Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202414504
Abstract: Despite significant therapeutic advances, cumulative DOX‐induced cardiotoxicity (DIC) events remain unacceptably high. Recent evidence has underscored the critical role of impaired glycolytic metabolism in cardiovascular damage. Neuraminidase 1 (NEU1), a member of the neuraminidase family,… read more here.
Keywords: cardiotoxicity; neuraminidase; glycolytic metabolism; nrf2 hif1 ... See more keywords
Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202505270
Abstract: The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity. ALYREF, a nuclear protein that preserves genomic stability through interactions with intranuclear components or as an m⁵C‐binding regulator of mRNA… read more here.
Keywords: dna damage; alyref; phase separation; cardiotoxicity ... See more keywords
Ixazomib cardiotoxicity: A possible class effect of proteasome inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24608
Abstract: The introduction of bortezomib has revolutionized the treatment of multiple myeloma (MM) and significantly improved outcomes in MM patients. Similar to many other chemotherapeutic agents, there are numerous reports of bortezomib-induced cardiotoxicity. Furthermore, the FDA… read more here.
Keywords: ixazomib; induced cardiotoxicity; proteasome inhibitors; treatment ... See more keywords
Cardioprotective effect of silymarin nanoemulsion on 5-fluorouracil-induced cardiotoxicity in rats.
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200060
Abstract: 5-Fluorouracil (5-FU)-associated cardiotoxicity has been ranked as the second most common cause of cardiotoxicity induced by chemotherapeutic drugs after anthracyclines. In the present study, we investigated the protective impacts of silymarin (SIL) and silymarin nanoemulsion… read more here.
Keywords: fluorouracil; silymarin nanoemulsion; sil sln; cardiotoxicity ... See more keywords
Concurrent epirubicin and trastuzumab use increases complete pathological response rate without additional cardiotoxicity in patients with human epidermal growth factor receptor 2‐positive early breast cancer: A meta‐regression analysis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70005
Abstract: Due to cardiotoxicity concerns, the concurrent use of epirubicin and trastuzumab has not been fully studied. This study aimed to examine the cardiotoxicity and pathological complete response (pCR) rate associated with the concurrent regimens in… read more here.
Keywords: cancer; cardiotoxicity; concurrent; human epidermal ... See more keywords
High neutrophil‐to‐lymphocyte ratio as an early sign of cardiotoxicity in breast cancer patients treated with anthracycline
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Cardiology"
DOI: 10.1002/clc.23966
Abstract: Cardiotoxicity, defined mainly as left ventricle (LV) dysfunction, is a significant side effect of anthracyclines (ANT) therapy. The need for an early simple marker to identify patients at risk is crucial. A high neutrophil‐to‐lymphocyte ratio… read more here.
Keywords: lymphocyte ratio; cancer patients; cardiotoxicity; high neutrophil ... See more keywords
Gemcitabine induced cardiomyopathy: a case of multiple hit cardiotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12113
Abstract: Gemcitabine is a commonly used antineoplastic agent used to treat a variety of cancers with rarely reported cardiac side effects. We describe a case of a 67‐year‐old woman with follicular lymphoma who experienced a rarely… read more here.
Keywords: gemcitabine; case; multiple hit; cardiotoxicity ... See more keywords
Troponins and natriuretic peptides to detect cardiotoxicity: useful biomarkers or paradise lost?
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1676
Abstract: In the past decades potent antineoplastic treatments brought hope to the millions of patients with cancer. As a result of increased survival rates and prolonged life expectancy, cardiotoxicity presents as a significant complication of several… read more here.
Keywords: peptides detect; detect cardiotoxicity; cardiotoxicity; antineoplastic treatments ... See more keywords