Multiscale Anisotropic Scaffold Integrating 3D Printing and Electrospinning Techniques as a Heart-on-a-chip Platform for Evaluating Drug-induced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300719
Abstract: Cardiac safety assessments are significant in drug discovery, as drug-induced cardiotoxicity is the primary cause of drug attrition. Despite heart-on-a-chip technology having become an increasingly popular tool for evaluating drug-induced cardiotoxicity, its development remains a… read more here.
Keywords: drug induced; induced cardiotoxicity; cardiotoxicity; drug ... See more keywords
Investigating and Resolving Cardiotoxicity Induced by COVID‐19 Treatments using Human Pluripotent Stem Cell‐Derived Cardiomyocytes and Engineered Heart Tissues
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DOI: 10.1002/advs.202203388
Abstract: Coronavirus disease 2019 continues to spread worldwide. Given the urgent need for effective treatments, many clinical trials are ongoing through repurposing approved drugs. However, clinical data regarding the cardiotoxicity of these drugs are limited. Human… read more here.
Keywords: cell; stem cell; pluripotent stem; human pluripotent ... See more keywords
Ixazomib cardiotoxicity: A possible class effect of proteasome inhibitors
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DOI: 10.1002/ajh.24608
Abstract: The introduction of bortezomib has revolutionized the treatment of multiple myeloma (MM) and significantly improved outcomes in MM patients. Similar to many other chemotherapeutic agents, there are numerous reports of bortezomib-induced cardiotoxicity. Furthermore, the FDA… read more here.
Keywords: ixazomib; induced cardiotoxicity; proteasome inhibitors; treatment ... See more keywords
Cardioprotective effect of silymarin nanoemulsion on 5-fluorouracil-induced cardiotoxicity in rats.
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DOI: 10.1002/ardp.202200060
Abstract: 5-Fluorouracil (5-FU)-associated cardiotoxicity has been ranked as the second most common cause of cardiotoxicity induced by chemotherapeutic drugs after anthracyclines. In the present study, we investigated the protective impacts of silymarin (SIL) and silymarin nanoemulsion… read more here.
Keywords: fluorouracil; silymarin nanoemulsion; sil sln; cardiotoxicity ... See more keywords
High neutrophil‐to‐lymphocyte ratio as an early sign of cardiotoxicity in breast cancer patients treated with anthracycline
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DOI: 10.1002/clc.23966
Abstract: Cardiotoxicity, defined mainly as left ventricle (LV) dysfunction, is a significant side effect of anthracyclines (ANT) therapy. The need for an early simple marker to identify patients at risk is crucial. A high neutrophil‐to‐lymphocyte ratio… read more here.
Keywords: lymphocyte ratio; cancer patients; cardiotoxicity; high neutrophil ... See more keywords
Gemcitabine induced cardiomyopathy: a case of multiple hit cardiotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12113
Abstract: Gemcitabine is a commonly used antineoplastic agent used to treat a variety of cancers with rarely reported cardiac side effects. We describe a case of a 67‐year‐old woman with follicular lymphoma who experienced a rarely… read more here.
Keywords: gemcitabine; case; multiple hit; cardiotoxicity ... See more keywords
Troponins and natriuretic peptides to detect cardiotoxicity: useful biomarkers or paradise lost?
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1676
Abstract: In the past decades potent antineoplastic treatments brought hope to the millions of patients with cancer. As a result of increased survival rates and prolonged life expectancy, cardiotoxicity presents as a significant complication of several… read more here.
Keywords: peptides detect; detect cardiotoxicity; cardiotoxicity; antineoplastic treatments ... See more keywords
Evaluating biomarkers as predictors of cancer therapy cardiotoxicity: all you need is a meta‐analysis? Reply
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1834
Abstract: References 1. Michel L, Mincu RI, Mahabadi AA, Settelmeier S, Al-Rashid F, Rassaf T, Totzeck M. Troponins and brain natriuretic peptides for the prediction of cardiotoxicity in cancer patients: a meta-analysis. Eur J Heart Fail… read more here.
Keywords: heart; cardiotoxicity; cancer; cancer therapy ... See more keywords
Maduramicin induces cardiotoxicity via Rac1 signaling‐independent methuosis in H9c2 cells
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DOI: 10.1002/jat.4175
Abstract: Maduramicin frequently induces severe cardiotoxicity in target and nontarget animals in clinic. Apoptotic and non‐apoptotic cell death mediate its cardiotoxicity; however, the underlying non‐apoptotic cell death induced by maduramicin remains unclear. In current study, a… read more here.
Keywords: h9c2 cells; cardiotoxicity; h9c2; methuosis ... See more keywords
Integrating analysis of circular RNA and mRNA expression profiles in doxorubicin induced cardiotoxicity mice
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DOI: 10.1002/jat.4257
Abstract: Doxorubicin (DOX)‐induced cardiotoxicity impedes its clinical application, but the mechanisms have not been thoroughly elucidated. Based on circRNA and mRNA expression profiles, we illustrated RNA expression signature changes during DOX‐induced cardiotoxicity; mechanism exploration and biomarkers… read more here.
Keywords: expression profiles; dox induced; induced cardiotoxicity; mrna expression ... See more keywords
Protective effects of salvianolic acid A on clozapine‐induced cardiotoxicity in zebrafish
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DOI: 10.1002/jat.4368
Abstract: The clinical use of clozapine (CLZ), an atypical antipsychotic drug, was affected by side effects, such as cardiotoxicity. We selected normally developing zebrafish embryos to explore the antagonism of salvianolic acid A (SAA) against clozapine‐induced… read more here.
Keywords: induced cardiotoxicity; cardiotoxicity; salvianolic acid; clozapine induced ... See more keywords