Potential Role and Limitations of Estimated Glomerular Filtration Rate Slope Assessment in Cardiovascular Trials: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2021.5151
Abstract: Importance Cardiovascular trials have traditionally been underpowered to assess advanced chronic kidney disease (CKD) outcomes, and when included as a secondary end point, trials have used progression of CKD as incidence of some variation of… read more here.
Keywords: glomerular filtration; slope; estimated glomerular; progression ... See more keywords
Early termination of cardiovascular trials as a consequence of poor accrual: analysis of ClinicalTrials.gov 2006–2015
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DOI: 10.1136/bmjopen-2016-013482
Abstract: Objectives To present a snapshot of experimental cardiovascular research with a focus on geographical and temporal patterns of early termination due to poor accrual. Setting The Aggregate Analysis of ClinicalTrials.gov (AACT) database, reflecting ClinicalTrials.gov as… read more here.
Keywords: cardiovascular trials; analysis clinicaltrials; clinicaltrials gov; early termination ... See more keywords
Accrual monitoring in cardiovascular trials
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DOI: 10.1136/openhrt-2017-000720
Abstract: Objective To provide brief guidance on how to design accrual monitoring activities in a clinical trial protocol. Setting Two completed clinical trials that did not achieve the planned sample size, the Cost of Strategies After… read more here.
Keywords: cardiovascular trials; accrual monitoring; trial; monitoring cardiovascular ... See more keywords