Extracellular vesicles and oncogenic signaling
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12855
Abstract: In recent years, extracellular vesicles (EVs) emerged as potential diagnostic and prognostic markers for cancer therapy. While the field of EV research is rapidly developing and their application as vehicles for therapeutic cargo is being… read more here.
Keywords: extracellular vesicles; oncogenic signaling; signaling cascades; vesicles oncogenic ... See more keywords
Red/Far-Red Light Switchable Cargo Attachment and Release in Bacteria-Driven Microswimmers.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900956
Abstract: In bacteria-driven microswimmers, i.e., bacteriabots, artificial cargos are attached to flagellated chemotactic bacteria for active delivery with potential applications in biomedical technology. Controlling when and where bacteria bind and release their cargo is a critical… read more here.
Keywords: red far; red light; far red; bacteria driven ... See more keywords
Multifunctional 3D‐Printed Pollen Grain‐Inspired Hydrogel Microrobots for On‐Demand Anchoring and Cargo Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202209812
Abstract: While a majority of wireless microrobots have shown multi‐responsiveness to implement complex biomedical functions, their functional executions are strongly dependent on the range of stimulus inputs, which curtails their functional diversity. Furthermore, their responsive functions… read more here.
Keywords: cargo; grain inspired; multifunctional printed; pollen ... See more keywords
Bro1 family proteins harmonize cargo sorting with vesicle formation
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100276
Abstract: The Endosomal Sorting Complexes Required for Transport (ESCRTs) drive membrane remodeling in a variety of cellular processes that include the formation of endosomal intralumenal vesicles (ILVs) during multivesicular body (MVB) biogenesis. During MVB sorting, ESCRTs… read more here.
Keywords: cargo; proteins harmonize; harmonize cargo; formation ... See more keywords
Stimulus‐dependent modifications in astrocyte‐derived extracellular vesicle cargo regulate neuronal excitability
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23708
Abstract: Extracellular vesicles have now emerged as key players in cell‐to‐cell communication. This is particularly important in the central nervous system, where glia–neuron cross‐talk helps maintain normal neuronal function. Astrocyte‐derived extracellular vesicles (ADEVs) secreted constitutively promote… read more here.
Keywords: response; stimulus; adevs secreted; derived extracellular ... See more keywords
Mitochondrial cargo export in exosomes: Possible pathways and implication in disease biology
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30967
Abstract: Exosome biogenesis occurs parallel to multiple endocytic traffic routes. These coexisting routes drive cargo loading in exosomes via overlapping of exosome biogenesis with endosomal pathways. One such pathway is autophagy which captures damaged intracellular organelles… read more here.
Keywords: cargo; cargo export; export exosomes; exosome biogenesis ... See more keywords
Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12002
Abstract: Abstract Hypoxia is an essential hallmark of several serious diseases such as cardiovascular and metabolic disorders and cancer. A decline in the tissue oxygen level induces hypoxic responses in cells which strive to adapt to… read more here.
Keywords: extracellular vesicles; vesicles review; review methods; hypoxia extracellular ... See more keywords
Crosslinked and Multi-Responsive Polymeric Vesicles as A Platform to Study Enzyme-mediated Undocking Behavior: Towards Future Artificial Organelle Communication.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200885
Abstract: Various cellular functions are successfully mimicked, opening the door to the next generation of therapeutic approaches and systems biology. Here, the first steps are taken towards the construction of artificial organelles for mimicking cell communication… read more here.
Keywords: cargo; communication; multi responsive; polymeric vesicles ... See more keywords
Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600371
Abstract: Epidemiological studies suggest that diabetes and obesity increases the risk of colorectal cancer (CRC) and lowers the patient survival rate. An important attribute in diabetes and obesity is the presence of high levels of growth… read more here.
Keywords: pi3k; pi3k akt; evs secreted; signalling pathway ... See more keywords
Protein Delivery to Cytosol by Cell-Penetrating Peptide Bearing Tandem Repeat Penetration-Accelerating Sequence.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1752-6_18
Abstract: Pas2r12 is comprised of a repeat of the penetration-accelerating sequence (Pas) (Pas2: FFLIG-FFLIG) and D-form dodeca-arginine (r12), a cell-penetrating peptide. Pas2r12 significantly enhances cytosolic delivery of cargo proteins, including enhanced green fluorescent protein and immunoglobulin… read more here.
Keywords: repeat penetration; penetration accelerating; delivery; accelerating sequence ... See more keywords
An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2541-z
Abstract: PurposeDrug-induced liver injuries (DILI) comprise a significant proportion of adverse drug reactions leading to hospitalizations and death. One frequent DILI is granulomatous inflammation from exposure to harmful metabolites that activate inflammatory pathways of immune cells… read more here.
Keywords: granulomatous inflammation; drug induced; drug; associated macrophages ... See more keywords