Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy
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DOI: 10.1126/sciadv.abg4922
Abstract: Reconstitution experiments show how different cargo receptors engage the autophagy machinery in unique ways to lipidate LC3. Selective autophagy of damaged mitochondria, protein aggregates, and other cargoes is essential for health. Cargo initiates phagophore biogenesis,… read more here.
Keywords: selective autophagy; cargo receptors; lc3 lipidation; cargo ... See more keywords