Mechanism of cargo sorting into small extracellular vesicles.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1977767
Abstract: Extracellular vesicles (EVs) are special membranous structures released by almost every cell type that carry and protect some biomolecules from being degraded. They transport important signaling molecules involved in cell communication, migration, and numerous physiological… read more here.
Keywords: extracellular vesicles; mechanism cargo; cargo sorting; sorting small ... See more keywords
A cargo-sorting DNA robot
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DOI: 10.1126/science.aan6558
Abstract: Sorting molecules with DNA robots Single-stranded DNA robots can move over the surface of a DNA origami sheet and sort molecular cargoes. Thubagere et al. developed a simple algorithm for recognizing two types of molecular… read more here.
Keywords: cargo sorting; dna; dna robots; dna robot ... See more keywords
Vacuolar H+-ATPase dysfunction rescues intralumenal vesicle cargo sorting in yeast lacking PI(3,5)P2 or Doa4.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.258459
Abstract: Endosomes undergo a maturation process highlighted by a reduction in lumenal pH, a conversion of surface markers that prime endosome-lysosome fusion, and the sequestration of ubiquitinated transmembrane protein cargoes within intralumenal vesicles (ILVs). We investigated… read more here.
Keywords: lacking doa4; cargo sorting; vacuolar atpase; yeast lacking ... See more keywords
Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.643769
Abstract: Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein complexes. The ESCRT machinery is comprised of five unique oligomeric complexes with distinct functions.… read more here.
Keywords: protein; tom1; protein trafficking; cargo sorting ... See more keywords
An emerging role of KRAS in biogenesis, cargo sorting and uptake of cancer-derived extracellular vesicles.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2021-0332
Abstract: Extracellular vesicles (EVs) are nanovesicles secreted for intercellular communication with endosomal network regulating secretion of small EVs (or exosomes) that play roles in cancer progression. As an essential oncoprotein, Kirsten rat sarcoma virus (KRAS) is… read more here.
Keywords: role kras; extracellular vesicles; biogenesis cargo; cancer ... See more keywords
Regulation of exosome production and cargo sorting
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.53671
Abstract: Cellular communication can be mediated by the exchange of biological information, mainly in the form of proteins and RNAs. This can occur when extracellular vesicles, such as exosomes, secreted by a donor cell are internalized… read more here.
Keywords: cargo sorting; regulation exosome; exosome production; production cargo ... See more keywords
Insights into cargo sorting by SNX32 and its role in neurite outgrowth
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.84396
Abstract: Sorting nexins (SNX) are a family of proteins containing the Phox homology domain, which shows a preferential endo-membrane association and regulates cargo sorting processes. Here, we established that SNX32, an SNX-BAR (Bin/Amphiphysin/Rvs) sub-family member associates… read more here.
Keywords: sorting snx32; snx32; role; insights cargo ... See more keywords