Multiple layers of spatial regulation coordinate axonal cargo transport
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2021.03.012
Abstract: Nerve axons are shaped similar to long electric wires to quickly transmit information from one end of the body to the other. To remain healthy and functional, axons depend on a wide range of cellular… read more here.
Keywords: transport; layers spatial; spatial regulation; cargo ... See more keywords
MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.03.046
Abstract: Polarized cargo transport is essential for neuronal function. However, the minimal basic components required for selective cargo sorting and distribution in neurons remain elusive. We found that in sensory neurons the axon initial segment is… read more here.
Keywords: filtering zone; sensory neurons; cargo; cargo transport ... See more keywords
Colloidal shuttles for programmable cargo transport
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01956-9
Abstract: The active transport of cargo molecules within cells is essential for life. Developing synthetic strategies for cargo control in living or inanimate thermal systems could lead to powerful tools to manipulate chemical gradients at the… read more here.
Keywords: programmable cargo; shuttles programmable; colloidal shuttles; cargo ... See more keywords
Rab6 is required for rapid, cisternal-specific, intra-Golgi cargo transport
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73276-w
Abstract: Rab6, the most abundant Golgi associated small GTPase, consists of 2 equally common isoforms, Rab6A and Rab6A′, that differ in 3 amino acids and localize to trans Golgi cisternae. The two isoforms are largely redundant… read more here.
Keywords: trans golgi; golgi; transport; rab6 ... See more keywords
Cargo transport through the nuclear pore complex at a glance.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.247874
Abstract: Bidirectional transport of macromolecules across the nuclear envelope is a hallmark of eukaryotic cells, in which the genetic material is compartmentalized inside the nucleus. The nuclear pore complex (NPC) is the major gateway to the… read more here.
Keywords: transport; pore complex; nuclear pore; cargo ... See more keywords
Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.82228
Abstract: Bidirectional cargo transport in neurons requires competing activity of motors from the kinesin-1, -2 and -3 superfamilies against cytoplasmic dynein-1. Previous studies demonstrated that when kinesin-1 attached to dynein-dynactin-BicD2 (DDB) complex, the tethered motors move… read more here.
Keywords: bidirectional transport; cargo transport; kinesin motors; transport ... See more keywords