Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity
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DOI: 10.1007/s00213-018-4874-z
Abstract: RationaleAberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in the rat phencyclidine (PCP)-induced model of schizophrenia; however, little is known about its in vivo neurochemistry.ObjectivesThe study… read more here.
Keywords: cariprazine aripiprazole; serotonin; locomotor activity; extracellular levels ... See more keywords
Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial
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DOI: 10.1016/s0140-6736(17)30060-0
Abstract: BACKGROUND Although predominant negative symptoms of schizophrenia can be severe enough to cause persistent impairment, effective treatment options are lacking. We aimed to assess the new generation antipsychotic cariprazine in adult patients with predominant negative… read more here.
Keywords: randomised double; negative symptoms; treatment; predominant negative ... See more keywords
Long-term effects of aripiprazole exposure on monoaminergic and glutamatergic receptor subtypes: comparison with cariprazine
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DOI: 10.1017/s1092852916000894
Abstract: Objective This study examined the chronic effects of aripiprazole and cariprazine on serotonin (5-HT1A and 5-HT2A) and glutamate (NMDA and AMPA) receptor subtypes. In addition, the effects of aripiprazole on D2 and D3 receptors were… read more here.
Keywords: receptor subtypes; effects aripiprazole; aripiprazole cariprazine; receptor ... See more keywords
Economic Outcomes with Adjunctive Cariprazine and Other Atypical Antipsychotics in Patients with Major Depressive Disorder
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DOI: 10.1017/s1092852923001906
Abstract: Abstract Introduction Patients with major depressive disorder (MDD) who have inadequate responses to antidepressants (ADs) can benefit from augmentation with atypical antipsychotics (AAs). Cariprazine, a D3/D2 receptor partial agonist, is approved for schizophrenia and for… read more here.
Keywords: statistically significantly; major depressive; cariprazine; patients major ... See more keywords
Safety and Tolerability of Cariprazine for the Adjunctive Treatment of Major Depressive Disorder: A Pooled Analysis of Phase 2B and 3 Clinical Trials
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DOI: 10.1017/s1092852923001992
Abstract: Abstract Background Cariprazine has been shown to be efficacious in placebo-controlled clinical trials. In this pooled analysis, the safety of cariprazine in patients with major depressive disorder (MDD) with inadequate response to antidepressants was evaluated… read more here.
Keywords: safety; cariprazine; treated patients; placebo controlled ... See more keywords
The efficacy of cariprazine on function in patients with bipolar depression: a post hoc analysis of a randomized controlled trial
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DOI: 10.1080/03007995.2021.1932446
Abstract: Abstract Introduction Individuals with bipolar depression often experience functional impairment that interferes with recovery. These analyses examined the effects of cariprazine on functional outcomes in patients with bipolar I disorder. Methods Prespecified analyses of data… read more here.
Keywords: post hoc; depression; bipolar depression; patients bipolar ... See more keywords
Cariprazine for treating psychosis: an updated meta-analysis
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DOI: 10.1080/13651501.2022.2071740
Abstract: Abstract Purpose Early treatment of psychotic illness improves outcomes, reduces relapse rates and should not be delayed. Cariprazine is a promising antipsychotic drug and may be a valuable resource when clinicians are in doubt if… read more here.
Keywords: psychosis independently; meta analysis; cariprazine; treating psychosis ... See more keywords
Cariprazine as a therapeutic option for schizophrenia: a drug evaluation
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DOI: 10.1080/14656566.2020.1845315
Abstract: ABSTRACT Introduction: Schizophrenia is a very disabling condition that may result in a significant impairment of individual, professional, and social adjustments. Antipsychotics (APs), the first-line treatment for schizophrenia, in many cases modify the course of… read more here.
Keywords: schizophrenia; cariprazine therapeutic; therapeutic option; schizophrenia drug ... See more keywords
Cariprazine for the treatment of bipolar depression: a review
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DOI: 10.1080/14737175.2019.1580571
Abstract: ABSTRACT Introduction: Depressive symptoms and episodes dominate the course of bipolar disorder. The morbidity of bipolar disorder is disproportionately mediated by depressive symptoms; economic costs of bipolar disorder are also disproportionately due to unremitting depressive… read more here.
Keywords: depression; treatment bipolar; bipolar depression; bipolar disorder ... See more keywords
Cariprazine in Youth with Bipolar and Psychotic Disorders: A Retrospective Chart Review.
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DOI: 10.1089/cap.2019.0106
Abstract: Objective: To examine the potential effectiveness and tolerability of cariprazine in pediatric bipolar and psychotic disorders. Methods: We retrospectively reviewed the electronic health records of patients read more here.
Keywords: iqr; chart review; bipolar psychotic; day ... See more keywords
Cariprazine for the Treatment of Bipolar Disorder
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DOI: 10.1111/ppc.12150
Abstract: PURPOSE To review the data regarding a new antipsychotic, cariprazine. CONCLUSIONS Cariprazine is a dopamine D3, D2 partial agonist, with greater affinity to D3. It has been examined for schizophrenia, bipolar mania, bipolar depression, and… read more here.
Keywords: depression; treatment bipolar; treatment; cariprazine treatment ... See more keywords