Anticholinesterase and carbonic anhydrase inhibitory activities of natural carnosic acid derivatives: A comprehensive in vitro and in silico study
Sign Up to like & getrecommendations! Published in 2025 at "Archiv Der Pharmazie"
DOI: 10.1002/ardp.202400909
Abstract: This study investigates the anticholinesterase (acetylcholinesterase [AChE] and butyrylcholinesterase [BChE]) and carbonic anhydrase (CAI and CAII) inhibitory activities of carnosic acid and its natural derivatives, including carnosol, rosmanol, 7‐methoxy‐rosmanol, 12‐methoxy‐carnosic acid, and isorosmanol. Among the… read more here.
Keywords: carnosic acid; carbonic anhydrase; kcal mol; inhibitory activities ... See more keywords
Carnosic Acid as a Promising Agent in Protecting Mitochondria of Brain Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular neurobiology"
DOI: 10.1007/s12035-017-0842-6
Abstract: Carnosic acid (CA; C20H28O4), a phenolic diterpene characterized as an ortho-dihydroquinone-type molecule, is a pro-electrophile agent that becomes an electrophile after reacting with free radicals. The electrophile generated from CA interacts with and activates the… read more here.
Keywords: agent; promising agent; acid promising; agent protecting ... See more keywords
Carnosic acid induces apoptosis of hepatocellular carcinoma cells via ROS-mediated mitochondrial pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.09.005
Abstract: Carnosic acid (CA), an important bioactive phenolic diterpene mainly found in labiate plants, exerts various biological functions, including antioxidant, anti-inflammatory, antitumor, and neuroprotective activities. In the present study, we proved the deleterious effects of CA… read more here.
Keywords: hepatocellular carcinoma; hcc; mediated mitochondrial; ros ... See more keywords
Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase‐1 in human articular chondrocytes
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.04.018
Abstract: Abstract Osteoarthritis (OA) is common age‐associated disease, and associated with joint pain, mobility limitations and compromised overall quality of life. OA treatment is currently limited to pain management and joint arthroplasty at end stage disease.… read more here.
Keywords: cartilage degeneration; heme oxygenase; articular chondrocytes; human articular ... See more keywords
Effect of rosmarinic acid and carnosic acid on AGEs formation in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2016.11.056
Abstract: This work aimed to investigate the effect of the two main components of rosemary extracts, namely rosmarinic acid (RA) and carnosic acid (CA), on the formation of advanced glycation end-products (AGEs) in vitro. In the… read more here.
Keywords: rosmarinic acid; bsa; effect; acid carnosic ... See more keywords
Carnosic acid (CA) attenuates collagen‐induced arthritis in db/db mice via inflammation suppression by regulating ROS‐dependent p38 pathway
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.03.023
Abstract: Abstract Rheumatoid arthritis (RA) is a multifactorial autoimmune disease, characterized by inflammation of synovial joints. Carnosic acid (CA) is a phenolic diterpene isolated from Rosmarinus officinailis, playing a central role in cytoprotective responses to oxidative… read more here.
Keywords: dependent p38; inflammation; ros dependent; acid ... See more keywords
STABILITY OF SOME BIOLOGICALLY ACTIVE SUBSTANCES IN EXTRACTS AND PREPARATIONS BASED ON ST. JOHN’S WORT (HYPERICUM PERFORATUM L.) AND SAGE (SALVIA OFFICINALIS L.)
Sign Up to like & getrecommendations! Published in 2020 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2020.112879
Abstract: Abstract Quality, authenticity and stability control of medicinal plant materials and preparations based on them is an important challenge in industries using substances and materials derived from plants. St. John’s wort (Hypericum perforatum L.) and… read more here.
Keywords: perforatum; preparations based; stability; john wort ... See more keywords
Carnosic acid alleviates hyperlipidemia and insulin resistance by promoting the degradation of SREBPs via the 26S proteasome
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.01.040
Abstract: Abstract Carnosic acid (CA), from rosemary, a food additive used for long history in western countries, reduces triglyceride, cholesterol and glucose levels. However, the detailed mechanisms contributing to these effects remain unclear. Here we investigate… read more here.
Keywords: alleviates hyperlipidemia; via 26s; srebps via; srebps ... See more keywords
Modeling the peroxyl radical scavenging behavior of Carnosic acid: Mechanism, kinetics, and effects of physiological environments.
Sign Up to like & getrecommendations! Published in 2021 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2021.112950
Abstract: Carnosic acid (CA), a phenolic diterpene and abietane-type compound, is a potent natural antioxidant with medical benefits. The present paper elucidates, for the first time, the kinetics and the exact mechanism of the peroxyl radical… read more here.
Keywords: mechanism; modeling peroxyl; peroxyl radical; radical scavenging ... See more keywords
Structures and biological activities of new carnosic acid- and carnosol-related compounds generated by heat treatment of rosemary
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2019.01.005
Abstract: Abstract Carnosic acid (CA) and carnosol (CS) are components of rosemary reported to possess antioxidative and peroxisome proliferator-activated receptor gamma (PPARγ) transcriptional activities that are useful for preventing metabolic disorders. The aims of this study… read more here.
Keywords: related compounds; structures biological; acid carnosol; carnosic acid ... See more keywords
Attenuation of adjuvant-induced arthritis with carnosic acid by inhibiting mPGES-1, COX-2, and bone loss in male SD rats
Sign Up to like & getrecommendations! Published in 2024 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2024.2377984
Abstract: Abstract Objective Rheumatoid arthritis (RA), a chronic inflammatory disease, is characterized by joint swelling, cartilage erosion, and bone destruction. This study investigated the therapeutic efficacy of Carnosic acid (CA), a natural compound with anti-inflammatory and… read more here.
Keywords: carnosic acid; loss; inflammatory; bone loss ... See more keywords