Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.13258
Abstract: BACKGROUND Muscle wasting during cancer cachexia is mediated by protein degradation via autophagy and ubiquitin-linked proteolysis. These processes are sensitive to changes in intracellular pH ([pH]i ) and reactive oxygen species, which in skeletal muscle… read more here.
Keywords: carnosine; muscle wasting; muscle; nmol tissue ... See more keywords
Carnosine exhibits significant antiviral activity against Dengue and Zika virus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Peptide Science"
DOI: 10.1002/psc.3196
Abstract: Dengue virus (DENV) and Zika virus (ZIKV) are flaviviruses transmitted to humans by their common vector, Aedes mosquitoes. DENV infection represents one of the most widely spread mosquito‐borne diseases whereas ZIKV infection occasionally re‐emerged in… read more here.
Keywords: carnosine; antiviral activity; zika virus; dengue ... See more keywords
The anserine to carnosine ratio: an excellent discriminator between white and red meats consumed by free-living overweight participants of the PREVIEW study
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nutrition"
DOI: 10.1007/s00394-020-02230-3
Abstract: Background Biomarkers of meat intake hold promise in clarifying the health effects of meat consumption, yet the differentiation between red and white meat remains a challenge. We measure meat intake objectively in a free-living population… read more here.
Keywords: preview study; overweight participants; meat; carnosine ... See more keywords
Biochemical characterization of the catecholaldehyde reactivity of l-carnosine and its therapeutic potential in human myocardium
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2647-y
Abstract: Oxidative deamination of norepinephrine (NE) and dopamine (DA) by monoamine oxidase (MAO) generates the catecholaldehydes 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively, and H2O2. Catecholaldehydes are highly reactive electrophiles that have been implicated as causal factors… read more here.
Keywords: reactivity carnosine; catecholaldehyde; myocardium; reactivity ... See more keywords
Carnosine protects cardiac myocytes against lipid peroxidation products
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2676-6
Abstract: Endogenous histidyl dipeptides such as carnosine (β-alanine-l-histidine) form conjugates with lipid peroxidation products such as 4-hydroxy-trans-2-nonenal (HNE and acrolein), chelate metals, and protect against myocardial ischemic injury. Nevertheless, it is unclear whether these peptides protect… read more here.
Keywords: cardiac myocytes; lipid peroxidation; peroxidation products; carnosine ... See more keywords
Effect of L-Carnosine as adjunctive therapy in the management of children with autism spectrum disorder: a randomized controlled study.
Sign Up to like & getrecommendations! Published in 2020 at "Amino acids"
DOI: 10.1007/s00726-020-02909-1
Abstract: L-Carnosine is an amino acid that acts as an anti-oxidant, anti-toxic and neuroprotective agent. There is a paucity of data about the effectiveness of L-Carnosine in the management of autism spectrum disorder (ASD) in children.… read more here.
Keywords: therapy; autism; study; management ... See more keywords
An assessment of the transport mechanism and intraneuronal stability of L-carnosine.
Sign Up to like & getrecommendations! Published in 2021 at "Amino acids"
DOI: 10.1007/s00726-021-03094-5
Abstract: L-Carnosine (β-alanyl-L-histidine) is a well-known antioxidant and neuroprotector in various models on animals and cell cultures. However, while there is a plethora of data demonstrating its efficiency as a neuroprotector, there is a distinct lack… read more here.
Keywords: mechanism; transport; carnosine; stability ... See more keywords
Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4256-x
Abstract: Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia. In intact animals, the level of lipid hydroperoxides in the frontal… read more here.
Keywords: status; oxidative status; focal ischemia; different areas ... See more keywords
Self-assembled structures of ferrocene-l-carnosine conjugates
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2017.01.005
Abstract: Abstract Ferrocene- l -carnosine conjugates, Fc- l -Carnosine-OEt and Fc 2 - l -Carnosine-OEt , were synthesized and characterized by X-ray crystallographic analyses. The single-crystal X-ray structure determination of Fc- l -Carnosine-OEt was demonstrated to… read more here.
Keywords: carnosine conjugates; hydrogen; ferrocene carnosine; self assembled ... See more keywords
β-Alanine supplementation elevates intramuscular carnosine content and attenuates fatigue in men and women similarly but does not change muscle l-histidine content.
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition research"
DOI: 10.1016/j.nutres.2017.10.002
Abstract: β-Alanine (BA) supplementation results in elevated intramuscular carnosine content, enhancing buffering capacity during intense exercise. Although men have greater muscle carnosine content than women, elevations still appear to occur despite high baseline levels. Recent research… read more here.
Keywords: supplementation; content; men women; carnosine ... See more keywords
Dietary supplementation with L-carnosine improves patient-reported outcomes, autonomic nervous system performance, and brain metabolism in 3 adult patients with multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Nutrition research"
DOI: 10.1016/j.nutres.2020.09.008
Abstract: This pilot trial reports the effects of L-carnosine administration on autonomic nervous system performance, brain metabolism, and various patient- and clinician-reported outcomes in a case series of patients with multiple sclerosis (MS). We hypothesized that… read more here.
Keywords: reported outcomes; case; nervous system; autonomic nervous ... See more keywords