Reduced Muscular Carnosine in Proximal Myotonic Myopathy-A Pilot 1H-MRS Study.
Sign Up to like & getrecommendations! Published in 2025 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.70263
Abstract: OBJECTIVE Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias. A hallmark feature… read more here.
Keywords: myotonic myopathy; carnosine; type; proximal myotonic ... See more keywords
Enhancing the efficacy of cisplatin against breast cancer cells using carnosine‐functionalized magnetic nanoparticles
Sign Up to like & getrecommendations! Published in 2024 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.7417
Abstract: The majorities of chemotherapy drugs and drug‐delivery models have significant health concerns and cause undesirable side effects because they lack specificity and proper targeting systems and are too large. It is crucial to prioritize the… read more here.
Keywords: cancer; carnosine; cancer cells; cisplatin ... See more keywords
Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.13258
Abstract: BACKGROUND Muscle wasting during cancer cachexia is mediated by protein degradation via autophagy and ubiquitin-linked proteolysis. These processes are sensitive to changes in intracellular pH ([pH]i ) and reactive oxygen species, which in skeletal muscle… read more here.
Keywords: carnosine; muscle wasting; muscle; nmol tissue ... See more keywords
Carnosine exhibits significant antiviral activity against Dengue and Zika virus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Peptide Science"
DOI: 10.1002/psc.3196
Abstract: Dengue virus (DENV) and Zika virus (ZIKV) are flaviviruses transmitted to humans by their common vector, Aedes mosquitoes. DENV infection represents one of the most widely spread mosquito‐borne diseases whereas ZIKV infection occasionally re‐emerged in… read more here.
Keywords: carnosine; antiviral activity; zika virus; dengue ... See more keywords
The anserine to carnosine ratio: an excellent discriminator between white and red meats consumed by free-living overweight participants of the PREVIEW study
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nutrition"
DOI: 10.1007/s00394-020-02230-3
Abstract: Background Biomarkers of meat intake hold promise in clarifying the health effects of meat consumption, yet the differentiation between red and white meat remains a challenge. We measure meat intake objectively in a free-living population… read more here.
Keywords: preview study; overweight participants; meat; carnosine ... See more keywords
Biochemical characterization of the catecholaldehyde reactivity of l-carnosine and its therapeutic potential in human myocardium
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2647-y
Abstract: Oxidative deamination of norepinephrine (NE) and dopamine (DA) by monoamine oxidase (MAO) generates the catecholaldehydes 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively, and H2O2. Catecholaldehydes are highly reactive electrophiles that have been implicated as causal factors… read more here.
Keywords: reactivity carnosine; catecholaldehyde; myocardium; reactivity ... See more keywords
Carnosine protects cardiac myocytes against lipid peroxidation products
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DOI: 10.1007/s00726-018-2676-6
Abstract: Endogenous histidyl dipeptides such as carnosine (β-alanine-l-histidine) form conjugates with lipid peroxidation products such as 4-hydroxy-trans-2-nonenal (HNE and acrolein), chelate metals, and protect against myocardial ischemic injury. Nevertheless, it is unclear whether these peptides protect… read more here.
Keywords: cardiac myocytes; lipid peroxidation; peroxidation products; carnosine ... See more keywords
Effect of L-Carnosine as adjunctive therapy in the management of children with autism spectrum disorder: a randomized controlled study.
Sign Up to like & getrecommendations! Published in 2020 at "Amino acids"
DOI: 10.1007/s00726-020-02909-1
Abstract: L-Carnosine is an amino acid that acts as an anti-oxidant, anti-toxic and neuroprotective agent. There is a paucity of data about the effectiveness of L-Carnosine in the management of autism spectrum disorder (ASD) in children.… read more here.
Keywords: therapy; autism; study; management ... See more keywords
An assessment of the transport mechanism and intraneuronal stability of L-carnosine.
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DOI: 10.1007/s00726-021-03094-5
Abstract: L-Carnosine (β-alanyl-L-histidine) is a well-known antioxidant and neuroprotector in various models on animals and cell cultures. However, while there is a plethora of data demonstrating its efficiency as a neuroprotector, there is a distinct lack… read more here.
Keywords: mechanism; transport; carnosine; stability ... See more keywords
Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4256-x
Abstract: Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia. In intact animals, the level of lipid hydroperoxides in the frontal… read more here.
Keywords: status; oxidative status; focal ischemia; different areas ... See more keywords
Self-assembled structures of ferrocene-l-carnosine conjugates
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2017.01.005
Abstract: Abstract Ferrocene- l -carnosine conjugates, Fc- l -Carnosine-OEt and Fc 2 - l -Carnosine-OEt , were synthesized and characterized by X-ray crystallographic analyses. The single-crystal X-ray structure determination of Fc- l -Carnosine-OEt was demonstrated to… read more here.
Keywords: carnosine conjugates; hydrogen; ferrocene carnosine; self assembled ... See more keywords