Carnosol alleviates cisplatin–induced acute kidney injury by regulating apoptosis and pyroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12258
Abstract: The use of the common anticancer drug cisplatin (CP) in clinical practice often leads to acute kidney injury (AKI); however, no protective therapy is available. Therefore, new drugs that reduce the nephrotoxicity induced by CP… read more here.
Keywords: carnosol; injury; expression; kidney injury ... See more keywords
Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1‐mediated Nrf2/HO‐1 activation
Sign Up to like & getrecommendations! Published in 2023 at "Phytotherapy Research"
DOI: 10.1002/ptr.7749
Abstract: Excessive oxidative stress and apoptosis of ovarian granulosa cells lead to abnormal follicular development and ovulation disorders in polycystic ovary syndrome (PCOS). Carnosol is a plant‐derived polyphenol that has been proven to exhibit several cell… read more here.
Keywords: apoptosis; oxidative stress; polycystic ovary; kgn cells ... See more keywords
Carnosol alleviates sepsis‐induced pulmonary endothelial barrier dysfunction by targeting nuclear factor erythroid2‐related factor 2/sirtuin‐3 signaling pathway to attenuate oxidative damage
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8138
Abstract: Excessive reactive oxygen species production during acute lung injury (ALI) will aggravate the inflammatory process and endothelial barrier dysfunction. Carnosol is a natural phenolic diterpene with antioxidant and anti‐inflammatory properties, but its role in treating… read more here.
Keywords: factor; endothelial barrier; sepsis induced; carnosol ... See more keywords
Cellular mechanisms mediating the anti-cancer effects of carnosol on gingiva carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-60797-x
Abstract: Carnosol, a rosemary polyphenol, displays anticancer properties and is suggested as a safer alternative to conventional surgery, radiotherapy, and chemotherapy. Given that its effects on gingiva carcinoma have not yet been investigated, the aim of… read more here.
Keywords: carnosol; carcinoma; cell cycle; gingiva carcinoma ... See more keywords
Carnosol suppresses microglia cell inflammation and apoptosis through PI3K/AKT/mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2074448
Abstract: Abstract Context: Ischemic stroke is the most common type of acute cerebrovascular disease. Carnosol is a polyphenol compound extracted from rosemary. Objective: This study aimed to explore the effects of carnosol on the oxygen-glucose deprivation… read more here.
Keywords: pi3k akt; signaling pathway; mtor signaling; akt mtor ... See more keywords
Carnosol, a diterpene present in rosemary, increases ELP1 levels in familial Dysautonomia (FD) patient-derived cells and healthy adults: a possible therapy for FD.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac133
Abstract: Recent research on Familial Dysautonomia (FD) has focused on the development of therapeutics that facilitate the production of the correctly spliced, exon 20-containing, transcript in cells and individuals bearing the splice-altering, FD-causing, mutation in the… read more here.
Keywords: transcript; familial dysautonomia; carnosol; patient ... See more keywords
Carnosol Improved Lifespan and Healthspan by Promoting Antioxidant Capacity in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/5958043
Abstract: Carnosol, a phenolic diterpene, is one of the main constituents of Rosmarinus. It is known to possess a range of bioactivities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory properties. Nevertheless, the antiaging effects of carnosol have… read more here.
Keywords: lifespan healthspan; caenorhabditis elegans; improved lifespan; carnosol improved ... See more keywords
Carnosol Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells in vitro by Regulating the AMPK Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230418093254
Abstract: BACKGROUND Hepatocellular carcinoma (HCC) is one of the most malignant cancers in the world, and its 5-year survival rate is low. At present, for advanced primary liver cancer, the clinical treatment often adopts the systemic… read more here.
Keywords: signaling pathway; hcc; migration invasion; carnosol ... See more keywords
Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.664403
Abstract: Carnosol, a natural polyphenol abundant in edible plants such as sage, rosemary, and oregano, has shown promising anticancer activity against various types of cancers. Nonetheless, very little is known about its molecular mechanism of action… read more here.
Keywords: carnosol; breast cancer; activity; p300 ... See more keywords
Carnosol, a Rosemary Ingredient Discovered in a Screen for Inhibitors of SARM1-NAD+ Cleavage Activity, Ameliorates Symptoms of Peripheral Neuropathy
Sign Up to like & getrecommendations! Published in 2025 at "Antioxidants"
DOI: 10.3390/antiox14070808
Abstract: Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) is a nicotinamide adenine dinucleotide (NAD+) hydrolase involved in axonal degeneration and neuronal cell death. SARM1 plays a pivotal role in triggering the neurodegenerative processes that… read more here.
Keywords: sarm1; cleavage activity; nad cleavage; carnosol ... See more keywords
Carnosol ameliorates sevoflurane induced cognitive impairment in aged rats by suppressing NLRP3 inflammasome via activation of autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v22i11.6
Abstract: Purpose: To investigate the effect of carnosol on the progression of postoperative cognitive dysfunction (POCD) and to elucidate its mechanism of action. Methods: A cognitive impairment model rat induced by sevoflurane (SEV) was established. Dihydroethidium (DHE) assay… read more here.
Keywords: cognitive impairment; carnosol; sevoflurane induced; sevoflurane ... See more keywords