Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1‐mediated Nrf2/HO‐1 activation
Sign Up to like & getrecommendations! Published in 2023 at "Phytotherapy Research"
DOI: 10.1002/ptr.7749
Abstract: Excessive oxidative stress and apoptosis of ovarian granulosa cells lead to abnormal follicular development and ovulation disorders in polycystic ovary syndrome (PCOS). Carnosol is a plant‐derived polyphenol that has been proven to exhibit several cell… read more here.
Keywords: apoptosis; oxidative stress; polycystic ovary; kgn cells ... See more keywords
Carnosol suppresses microglia cell inflammation and apoptosis through PI3K/AKT/mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2074448
Abstract: Abstract Context: Ischemic stroke is the most common type of acute cerebrovascular disease. Carnosol is a polyphenol compound extracted from rosemary. Objective: This study aimed to explore the effects of carnosol on the oxygen-glucose deprivation… read more here.
Keywords: pi3k akt; signaling pathway; mtor signaling; akt mtor ... See more keywords
Carnosol, a diterpene present in rosemary, increases ELP1 levels in familial Dysautonomia (FD) patient-derived cells and healthy adults: a possible therapy for FD.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac133
Abstract: Recent research on Familial Dysautonomia (FD) has focused on the development of therapeutics that facilitate the production of the correctly spliced, exon 20-containing, transcript in cells and individuals bearing the splice-altering, FD-causing, mutation in the… read more here.
Keywords: transcript; familial dysautonomia; carnosol; patient ... See more keywords
Carnosol Improved Lifespan and Healthspan by Promoting Antioxidant Capacity in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/5958043
Abstract: Carnosol, a phenolic diterpene, is one of the main constituents of Rosmarinus. It is known to possess a range of bioactivities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory properties. Nevertheless, the antiaging effects of carnosol have… read more here.
Keywords: lifespan healthspan; caenorhabditis elegans; improved lifespan; carnosol improved ... See more keywords
Carnosol Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells in vitro by Regulating the AMPK Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230418093254
Abstract: BACKGROUND Hepatocellular carcinoma (HCC) is one of the most malignant cancers in the world, and its 5-year survival rate is low. At present, for advanced primary liver cancer, the clinical treatment often adopts the systemic… read more here.
Keywords: signaling pathway; hcc; migration invasion; carnosol ... See more keywords
Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.664403
Abstract: Carnosol, a natural polyphenol abundant in edible plants such as sage, rosemary, and oregano, has shown promising anticancer activity against various types of cancers. Nonetheless, very little is known about its molecular mechanism of action… read more here.
Keywords: carnosol; breast cancer; activity; p300 ... See more keywords