Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier‐Free Nanoassembly of Fluorinated Prodrug and siRNA
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202203019
Abstract: Chemoimmunotherapy has shown great potential to activate an immune response, but the immunosuppressive microenvironment associated with T cell exhaustion remains a challenge in cancer therapy. The proper immune‐modulatory strategy to provoke a robust immune response… read more here.
Keywords: cell; cold tumors; defense signaling; fluorinated prodrug ... See more keywords
Carrier-Free H2 O2 Self-Supplier for Amplified Synergistic Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205692
Abstract: Chemodynamic therapy (CDT) utilizes Fenton or Fenton-like reactions to convert hydrogen peroxide (H2 O2 ) into cytotoxic hydroxyl radicals (•OH) and draws extensive interest in tumor therapy. Nevertheless, high concentrations of glutathione (GSH) and insufficient… read more here.
Keywords: tumor therapy; therapy; carrier free; self ... See more keywords
Lipophilic Conjugates for Carrier-Free Delivery of RNA Importable into Human Mitochondria.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1270-5_4
Abstract: Defects in human mitochondrial genome can cause a wide range of clinical disorders that still do not have efficient therapies. The natural pathway of small noncoding RNA import can be exploited to address therapeutic RNAs into… read more here.
Keywords: carrier free; conjugates carrier; rna; carrier ... See more keywords
Photonuclear production of carrier-free radionuclides: 69mZn
Sign Up to like & getrecommendations! Published in 2017 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-017-1743-6
Abstract: The yields of 66Ga, 67Ga, 68Ga, 70Ga, 65Zn, and 69mZn upon irradiation of gallium with the natural isotopic composition by the bremsstrahlung photon beam with the energy up to 55 MeV were measured. The yield… read more here.
Keywords: photonuclear production; carrier free; production carrier; radionuclides 69mzn ... See more keywords
Carrier-free prodrug nanoparticles based on dasatinib and cisplatin for efficient antitumor in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2021.08.001
Abstract: Abstract Carrier-free drug self-delivery systems consisting of amphiphilic drug-drug conjugate (ADDC) with well-defined structure and nanoscale features have drawn much attention in tumor drug delivery. Herein, we report a simple and effective strategy to prepare… read more here.
Keywords: vivo; carrier free; dda nps; drug ... See more keywords
Carrier-free core-shell nanodrugs for synergistic two-photon photodynamic therapy of cervical cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2018.09.095
Abstract: Carrier-free nanodrugs named BCNPs were prepared by the coassembly of 2,5-bis(4-(diethylamino)benzylidene)cyclopentanone (BDBC) and curcumin (CCM) in the absence of surfactants. The as-synthesized BCNPs possess high dispersity and stability in aqueous media, along with favorable photostability… read more here.
Keywords: photodynamic therapy; two photon; photon photodynamic; carrier free ... See more keywords
Novel carrier-free, charge-reversal and DNA-affinity nanodrugs for synergistic cascade cancer chemo-chemodynamic therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2021.08.121
Abstract: The combination of chemotherapy (CT) and chemodynamic therapy (CDT) is an emerging therapeutic strategy for tumors; however, its therapeutic efficacy is usually impaired by the shortage of high-efficiency intracellular catalysts for CDT and the poor… read more here.
Keywords: charge reversal; novel carrier; carrier free;
Development of a carrier-free dry powder ofloxacin formulation with enhanced aerosolization properties.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.05.027
Abstract: Tuberculosis (TB) is a serious infectious disease that affects more than new 10 million patients each year. Many of these cases are resistant to first-line drugs so second-line ones, like fluoroquinolones, need to be incorporated… read more here.
Keywords: carrier free; formulation; ofloxacin; free dry ... See more keywords
Design and Evaluation of a Carrier-Free Prodrug-Based Palmitic-DEVD-Doxorubicin Conjugate for Targeted Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00490
Abstract: In the development of new drugs, typical polymer- or macromolecule-based nanocarriers suffer from manufacturing process complexity, unwanted systematic toxicity, and low loading capacity. However, carrier-free nanomedicines have made outstanding progress in drug delivery and pharmacokinetics,… read more here.
Keywords: devd dox; palmitic devd; carrier free; devd ... See more keywords
Carrier-Free Small Molecular Self-Assembly Based on Berberine and Curcumin Incorporated in Submicron Particles for Improving Antimicrobial Activity.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c22900
Abstract: Nanocarrier-based pesticide formulations have been severely restricted in agriculture practices due to their high-cost preparation process, poor loading capacity, and toxicity issues. To overcome these issues, carrier-free small molecular self-assembled submicron particles (SMPs) with an… read more here.
Keywords: antimicrobial activity; small molecular; molecular self; carrier free ... See more keywords
Injectable Carrier-Free Hydrogel Dressing with Anti-Multidrug-Resistant Staphylococcus aureus and Anti-Inflammatory Capabilities for Accelerated Wound Healing.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c15463
Abstract: Antibacterial hydrogels have gradually become a powerful weapon to treat bacterially infected wounds and accelerate healing. In this paper, we designed a small-molecule self-healing antibacterial hydrogel containing 100% drug-loaded benzyl 3β-amino-11-oxo-olean-12-en-30-oate (GN-Bn), which was governed… read more here.
Keywords: wound healing; hydrogel; anti inflammatory; carrier free ... See more keywords