Reinforcing Carrier‐Free Photothermal Nanodrugs Through Flavonol‐Driven Assembly
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202402455
Abstract: Carrier‐free nanodrugs that integrate chemodrugs and other therapeutic agents demonstrate good efficacy and minimized side effects, showing promise for combined therapy. However, a key challenge lies in enhancing the bioavailability and therapeutic potential of the… read more here.
Keywords: driven assembly; carrier; flavonol driven; free photothermal ... See more keywords
Microfluidic Synthesis of Carrier‐Free Full‐Active Metal‐Phenolic Nanocapsules for Tumor Chemo‐Chemodynamic‐Immune Therapy
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DOI: 10.1002/adfm.202417070
Abstract: Development of carrier‐free full‐active nanoplatforms to exert efficient tumor therapeutics and prevent tumor recurrence remains to be a challenging task. Herein, a microfluidic synthesis of self‐assembled carrier‐free gossypol (Gos)‐iron ion (Fe3+)‐toyocamycin (Toy) nanocapsules (GFT NCs)… read more here.
Keywords: gft ncs; full active; tumor; carrier free ... See more keywords
Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier‐Free Nanoassembly of Fluorinated Prodrug and siRNA
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202203019
Abstract: Chemoimmunotherapy has shown great potential to activate an immune response, but the immunosuppressive microenvironment associated with T cell exhaustion remains a challenge in cancer therapy. The proper immune‐modulatory strategy to provoke a robust immune response… read more here.
Keywords: cell; cold tumors; defense signaling; fluorinated prodrug ... See more keywords
Opsonization Inveigles Macrophages Engulfing Carrier‐Free Bilirubin/JPH203 Nanoparticles to Suppress Inflammation for Osteoarthritis Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202400713
Abstract: Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage destruction, synovitis, and osteophyte formation. Disease‐modifying treatments for OA are currently lacking. Because inflammation mediated by an imbalance of M1/M2 macrophages in the synovial cavities… read more here.
Keywords: nanoparticles suppress; jph203 nanoparticles; inflammation; jph203 ... See more keywords
Carrier‐free co‐delivery nanosystem based on prothioconazole and pyrimethanil to enhance fungicidal efficacy and reduce environmental risks
Sign Up to like & getrecommendations! Published in 2025 at "Pest Management Science"
DOI: 10.1002/ps.8838
Abstract: The conventional application of fungicides suffers from substantial off‐target loss due to photolysis, evaporation, and rain washing, resulting in risks to the environment and human health. To address these limitations, self‐assembled nanopesticides based on two… read more here.
Keywords: free delivery; delivery; based prothioconazole; nanosystem based ... See more keywords
Carrier-Free H2 O2 Self-Supplier for Amplified Synergistic Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205692
Abstract: Chemodynamic therapy (CDT) utilizes Fenton or Fenton-like reactions to convert hydrogen peroxide (H2 O2 ) into cytotoxic hydroxyl radicals (•OH) and draws extensive interest in tumor therapy. Nevertheless, high concentrations of glutathione (GSH) and insufficient… read more here.
Keywords: tumor therapy; therapy; carrier free; self ... See more keywords
Carrier-Free Biomimetic Organic Nanoparticles with Super-High Drug Loading for Targeted NIR-II Excitable Triple-Modal Bioimaging and Phototheranostics.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202406003
Abstract: Multimodal near-infrared II (NIR-II) theranostics combined with nanotechnology have emerged as promising treatments for cancer due to their noninvasive and high spatiotemporal nature. Traditional NIR-II theranostics typically comprise useless and massive inert carriers, resulting in… read more here.
Keywords: high drug; drug loading; drug; nir theranostics ... See more keywords
Novel Carrier-Free Nanomedicine for Regulating Macrophage Phenotype to Amplify Anti-Tumor Photoimmunotherapy.
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DOI: 10.1002/smll.202505304
Abstract: Photoimmunotherapy presents a significant development potential both in inducing anti-tumor immunity and regulating the tumor microenvironment. However, the immunosuppressive tumor microenvironment (ITM) severely impedes the infiltration and functional activity of immune cells, while conventional immunotherapy… read more here.
Keywords: photoimmunotherapy; tumor; nanomedicine; anti tumor ... See more keywords
Lipophilic Conjugates for Carrier-Free Delivery of RNA Importable into Human Mitochondria.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1270-5_4
Abstract: Defects in human mitochondrial genome can cause a wide range of clinical disorders that still do not have efficient therapies. The natural pathway of small noncoding RNA import can be exploited to address therapeutic RNAs into… read more here.
Keywords: carrier free; conjugates carrier; rna; carrier ... See more keywords
Photonuclear production of carrier-free radionuclides: 69mZn
Sign Up to like & getrecommendations! Published in 2017 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-017-1743-6
Abstract: The yields of 66Ga, 67Ga, 68Ga, 70Ga, 65Zn, and 69mZn upon irradiation of gallium with the natural isotopic composition by the bremsstrahlung photon beam with the energy up to 55 MeV were measured. The yield… read more here.
Keywords: photonuclear production; carrier free; production carrier; radionuclides 69mzn ... See more keywords
Carrier-free prodrug nanoparticles based on dasatinib and cisplatin for efficient antitumor in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2021.08.001
Abstract: Abstract Carrier-free drug self-delivery systems consisting of amphiphilic drug-drug conjugate (ADDC) with well-defined structure and nanoscale features have drawn much attention in tumor drug delivery. Herein, we report a simple and effective strategy to prepare… read more here.
Keywords: vivo; carrier free; dda nps; drug ... See more keywords