Biochemical Characterization and Analyses of Polysialic‐Acid‐Associated Carrier Proteins and Genes in Piglets during Neonatal Development
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700029
Abstract: Polysialic acid plays a key role in cancer metastasis and neurodevelopment. Our aim was to determine the developmental gene‐expression profiles for the two polysialyltransferases ST8Sia II and ST8Sia IV, neural cell‐adhesion molecules (NCAMs), SynCAM 1, neuropilin‐2 (NRP2) and… read more here.
Keywords: polysialic acid; st8sia st8sia; carrier proteins; brain ... See more keywords
Molecular Cross‐Talk between Nonribosomal Peptide Synthetase Carrier Proteins and Unstructured Linker Regions
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700030
Abstract: Nonribosomal peptide synthetases (NRPSs) employ multiple domains separated by linker regions to incorporate substrates into natural products. During synthesis, substrates are covalently tethered to carrier proteins that translocate between catalytic partner domains. The molecular parameters… read more here.
Keywords: linker regions; carrier; linker; nonribosomal peptide ... See more keywords
Binding of adenosine derivatives to carrier proteins may reduce their antiplatelet activity.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.113827
Abstract: Adenosine analogues have high affinity and selectivity for adenosine receptors (AR), and exhibit anti-platelet activity. Plasma proteins play an important role in the regulation of platelet function and may influence the action of anti-platelet compounds.… read more here.
Keywords: carrier proteins; platelet; activity; plasma proteins ... See more keywords
Probing Substrate Sequestration in Carrier Proteins using Vibrational Spectroscopy Labels
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1860
Abstract: Carrier proteins are considered “lynchpin” enzymes of biosynthetic pathways. The E. coli acyl carrier protein (ACP) is composed of multiple alpha helices that form a hydrophobic, solvent-protected pocket that sometimes provides a cavernous hiding spot… read more here.
Keywords: sequestration; probing substrate; spectroscopy; carrier proteins ... See more keywords
Solute carrier proteins and c-Myc: a strong connection in cancer progression.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.02.007
Abstract: Solute carrier proteins (SLCs), the most understudied and second largest group of membrane proteins, maintain cellular metabolic homeostasis via the export and import of various solute, ions, metabolites, and even drugs. Given the importance of… read more here.
Keywords: connection; solute carrier; cancer; progression ... See more keywords
Exploration of Recombinant Fusion Proteins YAPO and YAPL as Carrier Proteins for Glycoconjugate Vaccine Design against Streptococcus pneumoniae Infection.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00260
Abstract: Pneumolysin (Ply), pneumococcal surface protein A (PspA), and pneumococcal surface adhesin A (PsaA) are promising cell surface protein antigen targets for Streptococcus pneumoniae (Spn) vaccine development. Herein, we designed and recombined two fusion proteins, named… read more here.
Keywords: streptococcus pneumoniae; yapo yapl; fusion proteins; carrier proteins ... See more keywords
Artificial covalent linkage of bacterial acyl carrier proteins for fatty acid production
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52344-w
Abstract: Acyl carrier proteins (ACPs) are essential to the production of fatty acids. In some species of marine bacteria, ACPs are arranged into tandem repeats joined by peptide linkers, an arrangement that results in high fatty… read more here.
Keywords: kda; production; fatty acid; acyl carrier ... See more keywords
Making Weak Antigens Strong: Cross-Linking Peptides to KLH with Maleimide.
Sign Up to like & getrecommendations! Published in 2018 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot100016
Abstract: Haptens, which are small antigens such as peptides and drug compounds, are very weakly or nonimmunogenic by themselves and require the assistance of carrier proteins: complex molecules capable of eliciting a strong immune response in… read more here.
Keywords: antigens strong; strong cross; weak antigens; making weak ... See more keywords